376640-41-4|BVT 2733|CsnPharm

CAS No.: 376640-41-4

BVT 2733 Catalog No. CSN16289

Synonyms: BVT 2733

BVT 2733 is a small molecule, non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1(11β-HSD1).

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述BVT.2733 is a new, small molecule, non-steroidal, isoform-selective inhibitor of mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). It lowered hepatic PEPCK and glucose-6-phosphatase mRNA, blood glucose and serum insulin concentrations compared with vehicle treated mice^[4]. BVT-2733 exhibited an anti-inflammatory effect. BVT.2733 treatment could not only decrease body weight and improve metabolic homeostasis, but also suppress the inflammation of adipose tissue in diet-induced obese mice, shown as the down-regulated the expression of inflammation-related genes MCP-1, TNF-α and the number of infiltrated macrophages in vivo^[5]. Oral administration of 100mg/kg BVT-2733 twice daily for 2 weeks attenuated the arthritis severity and anti-CII level in CIA (collagen-induced arthritis) mice, decreased the levels of serum TNF-α, IL-1β, IL-6 and IL-17, and also significantly reduced synovial inflammation and joint destruction^[6].
动物研究
剂量
Mice: 100 mg/kg^[3] (p.o.), 200 mg/kg^[4] (p.o.)

给药途径
p.o.
参考文献

动物研究
剂量	Mice: 100 mg/kg^[3] (p.o.), 200 mg/kg^[4] (p.o.)
给药途径	p.o.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3312 mL
- 11.6562 mL
- 23.3124 mL
- 5 mM
- 0.4662 mL
- 2.3312 mL
- 4.6625 mL
- 10 mM
- 0.2331 mL
- 1.1656 mL
- 2.3312 mL

技术信息

CAS号

376640-41-4

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H21ClN4O3S2

运输

蓝冰

分子量

428.96

别名

BVT 2733

溶解度

DMSO	136.67 mg/mL (318.6 mM)
Water	insoluble

动物实验配方

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