|(E)-3-((1H-吲哚-3-基)亚甲基)-5-((E)-3,4-二甲氧基亚)-1-甲基哌啶-4-酮|CsnPharm

CAS No.: 1370032-19-1

CA-5f Catalog No. CSN24767

Synonyms: CA-5f

CA-5f is identified as a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. It exhibted potential clinical application for NSCLC therapy.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Macroautophagy/autophagy is a conserved eukaryotic cellular degradative process in which organelles and cellular proteins are sequestered in autophagosomes that subsequently fuse with lysosomes for further degradation and recycling. Autophagy plays essential roles in various normal cellular processes, including cell growth, proliferation, differentiation, development, ageing, and inflammation, to maintain cellular homeostasis ^[1]. CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion, which CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. CA-5f exhibited strong cytotoxicity against A549 non-small cell lung cancer (NSCLC) cells, but low cytotoxicity to normal human umbilical vein endothelial cells (HUVECs), by increasing mitochondrial-derived reactive oxygen species (ROS) production ^[1]. Moreover, CA-5f effectively suppressed the growth of A549 lung cancer xenograft as a single agent with an excellent tolerance in vivo ^[1].
参考文献

[1] Zhang L, Qiang P, Yu J, Miao Y, Chen Z, Qu J, Zhao Q, Chen Z, Liu Y, Yao X, Liu B, Cui L, Jing H, Sun G. Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. Autophagy. 2019 Mar;15(3):391-406. doi: 10.1080/15548627.2018.1511503. Epub 2018 Sep 6. PMID: 30145925; PMCID: PMC6351124.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5743 mL
- 12.8714 mL
- 25.7427 mL
- 5 mM
- 0.5149 mL
- 2.5743 mL
- 5.1485 mL
- 10 mM
- 0.2574 mL
- 1.2871 mL
- 2.5743 mL

技术信息

CAS号

1370032-19-1

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H24N2O3

运输

蓝冰

分子量

388.46

别名

CA-5f

溶解度

DMSO	97.5 mg/mL (251.0 mM)
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

CA-5f Catalog No. CSN24767

靶点选择性

请登录您的专属账户

确认信息