|(S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((R)-6-羟基-6-甲基庚烷-2-基)-7a-甲基六氢-1H-茚-4(2H)-亚基)亚乙基)-4-亚甲基环己醇一水合物|CsnPharm

CAS No.: 63283-36-3

Calcifediol monohydrate/骨化二醇一水合物 Catalog No. CSN16861

Synonyms: 25-hydroxy Vitamin D3 monohydrate;Calderol;Dedrogyl

Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM).

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实验方案

技术信息

生物活性

描述Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), a major circulating metabolite of vitamin D3, is a potent VDR inhibitor. Calcifediol in either liposomes or ethanolic solution has no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. Treatment of infected, human bronchial 16-HBE cells with Calcifediol liposomes results in a significant reduction in bacterial survival^[2]. The safer pharmacokinetic of the recent modified-release (MR) formulation of calcifediol was effective in replenishing 25(OH)D levels with minimal impact on vitamin D catabolism and fibroblast-growth factor-23 (FGF-23) activation^[3]. The inhibitory effects induced by VDR overexpression could be reversed by the VDR inhibitor, calcifediol^[4]. Extended-release calcifediol (ERC) is an orally administered prohormone of active vitamin D (1,25-dihydroxyvitamin D [1,25D]) designed to safely and sufficiently increase serum total 25-hydroxyvitamin D (25D) to reduce elevated parathyroid hormone (PTH) in patients with non-dialysis-chronic kidney disease (ND-CKD)^[5].
临床研究
NCT号适应症或疾病临床期招募状态预计完成时间地点
NCT03194334 Dietary Modification Not Applicable Completed - -
NCT03634917 Alcoholism Phase 3 Not yet recruiting April 30, 2020 -
参考文献

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03194334	Dietary Modification	Not Applicable	Completed	-	-
NCT03634917	Alcoholism	Phase 3	Not yet recruiting	April 30, 2020	-

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3886 mL
- 11.9431 mL
- 23.8862 mL
- 5 mM
- 0.4777 mL
- 2.3886 mL
- 4.7772 mL
- 10 mM
- 0.2389 mL
- 1.1943 mL
- 2.3886 mL

技术信息

CAS号	63283-36-3	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C27H46O3	运输	蓝冰
分子量	418.65	别名	25-hydroxy Vitamin D3 monohydrate;Calderol;Dedrogyl;Rayaldee;U-32070E;2,5-Hydroxyvitamin D3 monohydrate;骨化二醇一水合物

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Calcifediol monohydrate/骨化二醇一水合物 Catalog No. CSN16861

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