生物活性

• 描述Calicheamicin is a potent DNA crosslinker cytotoxic antibiotic.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00801489	Acute Myeloid Leukemia With In... more >>v(16)(p13.1q22); CBFB-MYH11 Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11 Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1 de Novo Myelodysplastic Syndrome High Risk Myelodysplastic Syndrome Inv(16) Myelodysplastic Syndrome With Excess Blasts t(16;16) t(8;21) Untreated Adult Acute Myeloid Leukemia Collapse <<	Phase 2	Recruiting	April 30, 2020	United States, Texas ... more >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Gautam Borthakur    713-563-1586       Principal Investigator: Gautam Borthakur Collapse <<
  NCT03531918	Acute Myeloid Leukemia ... more >> High-Grade Myeloid Neoplasm Collapse <<	Phase 1 Phase 2	Recruiting	July 1, 2025	United States, Washington ... more >> Fred Hutch/University of Washington Cancer Consortium Recruiting Seattle, Washington, United States, 98109 Contact: Roland Walters    206-667-3599    rwalter@fredhutch.org    Principal Investigator: Roland Walters Collapse <<
  NCT01409161	Acute Promyelocytic Leukemia W... more >>ith PML-RARA Collapse <<	Phase 2	Recruiting	October 31, 2019	United States, Texas ... more >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Kiran Naqvi    713-745-5073       Principal Investigator: Kiran Naqvi          MD Anderson Regional Care Center-Katy Not yet recruiting Houston, Texas, United States, 77094 Contact: Kiran Naqvi    713-745-5073       Principal Investigator: Kiran Naqvi          MD Anderson Regional Care Center-Bay Area Not yet recruiting Nassau Bay, Texas, United States, 77058 Contact: Kiran Naqvi    713-745-5073       Principal Investigator: Kiran Naqvi          MD Anderson Regional Care Center-Sugar Land Not yet recruiting Sugar Land, Texas, United States, 77478 Contact: Kiran Naqvi    713-745-5073       Principal Investigator: Kiran Naqvi          MD Anderson Regional Care Center-The Woodlands Not yet recruiting The Woodlands, Texas, United States, 77384 Contact: Kiran Naqvi    713-745-5073       Principal Investigator: Kiran Naqvi Collapse <<

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• 参考文献

• [1] Chang A, Singh S, et al. Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17649-54.

  [2] Ricart AD. Antibody-drug conjugates of calicheamicin derivative: gemtuzumab ozogamicin and inotuzumab ozogamicin. Clin Cancer Res. 2011 Oct 15;17(20):6417-6427.