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CAS No.: 59721-29-8

Camostat Mesylate/甲磺酸卡莫司他 Catalog No. CSN11492

Synonyms: Camostat mesilate;FOY305;FOY-S980

Camostat mesylate is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trypsin, prostasin and matriptase.

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400-920-2911

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技术信息

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描述Camostat mesylate (CM) is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trypsin, prostasin and matriptase. It also inhibits transmembrane serine protease TMPRSS2, suggesting that it could block entry of SARS-Cov-2 (COVID-19) into lung cells in vitro^[3]. In vivo, the oral administration of CM inhibited inflammation, cytokines expression and fibrosis in the pancreas. CM inhibited both MCP-1 (monocyte chemoattractant protein-1) and TNF-alpha production from monocytes, and proliferation and MCP-1 production from PSCs (panceatic stellate cells) ^[4]. Camostat mesilate (30 mg/kg; p.o.; twice a day for 9 days) blocks the spread and pathogenesis of SARS-CoV in a pathogenic mouse model^[5]. CM alleviated the detrimental effect of LPS on cell viability and inhibited LPS-induced TNF-α and IL-6 secretions in DF-1 chicken embryo fibroblasts^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0222 mL
- 10.1109 mL
- 20.2217 mL
- 5 mM
- 0.4044 mL
- 2.0222 mL
- 4.0443 mL
- 10 mM
- 0.2022 mL
- 1.0111 mL
- 2.0222 mL

技术信息

CAS号

59721-29-8

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H26N4O8S

运输

蓝冰

分子量

494.52

别名

Camostat mesilate;FOY305;FOY-S980;Camostat (mesylate);Foipan;Camostat Mesylate;甲磺酸卡莫司他

溶解度

DMSO	98.0 mg/mL (198.2 mM)
Water	31.0 mg/mL (62.7 mM)
Ethanol	Insoluble

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Camostat Mesylate/甲磺酸卡莫司他 Catalog No. CSN11492

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