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CAS No.: 5957-80-2

Carnosol/鼠尾草酚 Catalog No. CSN10554

Synonyms: NSC 39143;CCRIS-7122;HSDB-7680

Carnosol, a natural product isolated and purified from the herbs of Rosmarinus officinalis L., enhances the sensitivity of chemoresistant cancer cells to chemotherapeutic agents. Carnosol may as an agonist of TRPA1 with an EC50 value of 12.46 µM.

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技术信息

生物活性

描述Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM. Carnosol reduced anchorage-dependent and -independent gastric cancer growth by inhibiting the RSKs-CREB signaling pathway. Carnosol increased the G2/M phase and decreased S phase cell cycle and also induced apoptosis through the activation of caspases 9 and 7 and inhibition of Bcl-xL expression. Moreover, oral administration of carnosol suppressed patient-derived gastric tumor growth in an in vivo mouse model^[3]. Non-cytotoxic concentrations of carnosol inhibited the migration and invasion of MDA-MB-231 cells in wound healing and matrigel invasion assays. Carnosol significantly and markedly suppressed tumor growth and metastasis of breast cancer xenografts^[4]. Carnosol stimulated glucose uptake in L6 myotubes in a dose- and time-dependent manner, did not affect Akt, increased AMPK (AMP-activated kinase) phosphorylation and plasma membrane GLUT4 levels^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0265 mL
- 15.1323 mL
- 30.2647 mL
- 5 mM
- 0.6053 mL
- 3.0265 mL
- 6.0529 mL
- 10 mM
- 0.3026 mL
- 1.5132 mL
- 3.0265 mL

技术信息

CAS号

5957-80-2

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H26O4

运输

蓝冰

分子量

330.42

别名

NSC 39143;CCRIS-7122;HSDB-7680;鼠尾草酚

溶解度

DMSO	66.0 mg/mL (199.7 mM)

动物实验配方

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