CAS No.: 1218777-13-9
CAY10505 Catalog No. CSN19141
Synonyms: N/A
CAY10505 is dehydroxyl of AS-252424, which is a PI3Kγ inhibitor with IC50 of 33 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
动物研究 剂量 Rat: 0.6 mg/kg[2] (p.o.)
给药途径 p.o.
- 参考文献
- [1] Sun YY, Lin SH, et al. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. PLoS One. 2013 Jul 19;8(7):e69019.
- [2] Tyagi S, Sharma S, et al. Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats. Can J Physiol Pharmacol. 2012 Jul;90(7):881-5.
- [3] Sun YY, Lin SH, Lin HC, Hung CC, Wang CY, Lin YC, Hung KS, Lien CC, Kuan CY, Lee YH. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. PLoS One. 2013 Jul 19;8(7):e69019. doi: 10.1371/journal.pone.0069019. PMID: 23904909; PMCID: PMC3719842.
- [4] Tyagi S, Sharma S, Budhiraja RD. Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats. Can J Physiol Pharmacol. 2012 Jul;90(7):881-5. doi: 10.1139/y2012-089. Epub 2012 Jun 25. PMID: 22731503.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1218777-13-9 | 储存条件 |
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| 分子式 | C14H8FNO3S | 运输 | 蓝冰 | |
| 分子量 | 289.28 | 别名 | N/A |
