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CAS No.: 1438391-30-0

CC-401 HCl Catalog No. CSN17322

Synonyms: CC401 HCl;CC-401;JNK-401

CC-401 HCl is a selective and ATP-competitive JNK inhibitor with Ki values ranging in 25-50 nM.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The c-Jun N-terminal kinase (JNK) signaling plays an important role in tubular cell apoptosis. CC-401 is a potent, small-molecule JNK inhibitor with K_i values of 25-50nM for three forms of JNK. It inhibits JNK in cell-based assays at a concentration of 1-5μM. CC-401 dose-dependently inhibited sorbitol-induced phosphorylation of c-Jun in HK-2 human tubular epithelial cell line at doses of 0.25-4μM. The oral administration of rats underwent unilateral ureteral obstruction with CC-401 (100mg/kg, twice daily) for 7 days reduced interstitial volume, the accumulation of α-SMA+ myofibroblasts, and collagen IV deposition as compared to the vehicle-treated group. Rats treated with CC-401 also showed reduced mRNA expressions of TGF-β1, connective tissue growth factor, and collagen IV in the kidney compared with vehicle-treated animals^[3].
作用机制CC-401 is a JNK inhibitor that competitively binds to the ATP binding site of JNK, inhibiting the phosphorylation of the N-terminal activation domain of c-Jun^[3].
参考文献

[1] Vasilevskaya IA, Selvakumaran M, et al. Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents. Clin Cancer Res. 2015 Sep 15;21(18):4143-52.
[2] Uehara T, Bennett B, et al. JNK mediates hepatic ischemia reperfusion injury.J Hepatol. 2005 Jun;42(6):850-9.
[3] Ma FY, Flanc RS, Tesch GH, et al. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol. 2007;18(2):472-484. doi:10.1681/ASN.2006060604

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3533 mL
- 11.7667 mL
- 23.5335 mL
- 5 mM
- 0.4707 mL
- 2.3533 mL
- 4.7067 mL
- 10 mM
- 0.2353 mL
- 1.1767 mL
- 2.3533 mL

技术信息

CAS号

1438391-30-0

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H25ClN6O

运输

蓝冰

分子量

424.93

别名

CC401 HCl;CC-401;JNK-401

溶解度

DMSO	85.0 mg/mL (200.0 mM)
Ethanol	2.0 mg/mL (4.7 mM)

动物实验配方

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