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CAS No.: 285986-88-1

CCG-1423 Catalog No. CSN15952

Synonyms: CCG-1423

CCG-1423 inhibits RhoA/C-mediated gene transcription and the invasion of rho-overexpressing cell lines.

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技术信息

生物活性

描述Rho GTPases are molecular switches that regulate many essential cellular processes, including actin dynamics, gene transcription, cell-cycle progression and cell adhesion^[3]. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression^[4]. CCG-1423 is a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis. CCG-1423 selectively inhibited spontaneous PC-3 prostate cancer cell invasion through a Matrigel matrix in vitro, but not the Gαi-dependent LPA-stimulated SKOV-3 ovarian cancer cell invasion in vitro. At 100 μM, nearly complete inhibition of invasion was achieved with a lesser degree of toxicity than that induced by CCG-1423 at 10 μM^[5]. Pharmacological SRF inhibition by CCG-1423 reduced nuclear MKL1 and improved glucose uptake and tolerance in insulin-resistant mice in vivo^[6]. SRF binds to this site in vivo and the SRF inhibitor CCG-1423 completely blocks STARS proximal reporter activity in H9c2 cells^[7]. Pharmacological MKL-inhibition with CCG-1423 significantly inhibited CCN1 promoter activity as well as mRNA and protein expression^[8].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1990 mL
- 10.9951 mL
- 21.9901 mL
- 5 mM
- 0.4398 mL
- 2.1990 mL
- 4.3980 mL
- 10 mM
- 0.2199 mL
- 1.0995 mL
- 2.1990 mL

技术信息

CAS号

285986-88-1

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H13ClF6N2O3

运输

蓝冰

分子量

454.75

别名

CCG-1423

溶解度

DMSO	150.0 mg/mL (329.9 mM)
Water	insoluble

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