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CAS No.: 1700637-55-3

Synonyms: CD38 Inhibitor 1;CD38-IN-78c;CD38 Inhibitor 78c

CD38 inhibitor 1 is a potent CD38 inhibitor with IC50 values of 7.3 nM and 1.9 nM for hCD38 and mouse CD38, respectively.

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400-920-2911

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描述CD38 inhibitor 1 is a cell-permeable, orally bioavailable, non-toxic thiazolyl-quinolinone derivative compound that acts as a potent, selective and reversible inhibitor of CD38 (IC50 of human and mouse CD38 are 7.3 and 1.9 nM; Ki = 0.3 nM for human wt-CD38). It is shown to bind to catalytically active sites. Oral administration of CD38 inhibitor 1 at a dose of 30 mg/kg rapidly elevated the NAD levels in the liver, spleen and intestinal muscle tissues in both liver and gastrocnemius tissue of a diet-induced obese mouse^[1].
作用机制CD38 inhibitor 1 binds to catalytically active sites of the target^[1].
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技术信息

CAS号	1700637-55-3	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C22H27N3O3S	运输	蓝冰
分子量	413.53	别名	CD38 Inhibitor 1;CD38-IN-78c;CD38 Inhibitor 78c;Compound-78c;CD38i_78c;78c;Cluster of Differentiation 38 Inhibitor;MDK-7553;CD38IN-78c: CD38 inhibitor 78c

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