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CAS No.: 717899-97-3

CE-245677 Catalog No. CSN22174

Synonyms: CE-245,677

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.

规格	价格	促销价格	库存	数量

400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The Tie receptor tyrosine kinases play an important role in the development of endothelial tissues. The Tie receptors (Tie1 and Tie2) and their ligands (angiopoietins) are highly involved in the survival and functional integrity of the vasculature. CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with IC50 values of 4.7 and 1nM, respectively. It showed over 1000-fold selectivity against other angiogenic receptor tyrosine kinases, including kinase insert domain receptor, platelet-derived growth factor receptor, and fibroblast growth factor receptors, and gene family panels. CE-245677 also exhibited good oral bioavailability (F=80%) in rat pharmacokinetic study^[1].
参考文献

[1] Identification of selective, orally active Tie2 kinase inhibitors and discovery of CE-245,677 and PF-371,989

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9479 mL
- 9.7395 mL
- 19.4789 mL
- 5 mM
- 0.3896 mL
- 1.9479 mL
- 3.8958 mL
- 10 mM
- 0.1948 mL
- 0.9739 mL
- 1.9479 mL

技术信息

CAS号

717899-97-3

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H22Cl2N6O3

运输

蓝冰

分子量

513.38

别名

CE-245,677

溶解度

DMSO	120.0 mg/mL (233.7 mM) warming

动物实验配方

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