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CAS No.: 863513-91-1

Cebranopadol Catalog No. CSN13503

Synonyms: GRT6005

Cebranopadol is an analgesic NOP and opioid receptor agonist with Kis/EC50s of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, 18 nM/110 nM for human NOP, MOP, KOP and delta-opioid peptide (DOP) receptor, respectively.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Cebranopadol is an analgesic NOP and opioid receptor agonist with Kis/EC50s of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, 18 nM/110 nM for human NOP, MOP, KOP and delta-opioid peptide (DOP) receptor, respectively.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00878293	Diabetic Polyneuropathy	Phase 2	Completed	-	Germany ... more >> Investigator 3 Bad Oeynhausen, Germany Investigator 1 Mainz, Germany Investigator 2 Münster, Germany United Kingdom Investigator 4 Manchester, United Kingdom Collapse <<
NCT00872885	Post Operative Pain	Phase 2	Completed	-	United States, Texas ... more >> Premier Research Group Ltd Austin, Texas, United States, 78705 Collapse <<
NCT01725087	Low Back Pain	Phase 2	Completed	-	-

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参考文献

[1] de Guglielmo G, Matzeu A, et al. Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats. J Pharmacol Exp Ther. 2017 Sep;362(3):378-384.
[2] Linz K, Christoph T, et al. Cebranopadol: a novel potent analgesic nociceptin/orphanin FQ peptide and opioid receptor agonist. J Pharmacol Exp Ther. 2014 Jun;349(3):535-48.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6421 mL
- 13.2107 mL
- 26.4213 mL
- 5 mM
- 0.5284 mL
- 2.6421 mL
- 5.2843 mL
- 10 mM
- 0.2642 mL
- 1.3211 mL
- 2.6421 mL

技术信息

CAS号

863513-91-1

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H27FN2O

运输

蓝冰

分子量

378.48

别名

GRT6005

溶解度

DMSO	6.0 mg/mL (15.9 mM) warming
Water	Insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00878293	Diabetic Polyneuropathy	Phase 2	Completed	-	Germany ... more >> Investigator 3 Bad Oeynhausen, Germany Investigator 1 Mainz, Germany Investigator 2 Münster, Germany United Kingdom Investigator 4 Manchester, United Kingdom Collapse <<
NCT00872885	Post Operative Pain	Phase 2	Completed	-	United States, Texas ... more >> Premier Research Group Ltd Austin, Texas, United States, 78705 Collapse <<
NCT01725087	Low Back Pain	Phase 2	Completed	-	-
NCT01347671	Pain Diabetic... more >> Neuropathies Collapse <<	Phase 2	Completed	-	Bulgaria ... more >> Site 4502 Sofia, Bulgaria, 1431 Germany Site 4112 Aschaffenburg, Germany, 63739 Site 4109 Bad Oeynhausen, Germany, 32545 Site 4101 Berlin, Germany, 10117 Site 4110 Berlin, Germany, 13125 Site 4111 Dresden, Germany, 01307 Site 4107 Hamburg, Germany, 20253 Site 4117 Hamburg, Germany, 22587 Site 4108 Hannover, Germany, 30159 Site 4104 Hannover, Germany, 30167 Site 4115 Heidelberg, Germany, 69120 Site 4106 Kiel, Germany, 24119 Site 4102 Lübeck, Germany, 23562 4103 Mainz, Germany, 55116 Site 4105 Münster, Germany, 48145 Site 4113 Schwerin, Germany, 19055 Site 4116 Wangen, Germany, 88239 Romania Site 4405 Bucuresti, Romania, 010496 Site 4402 Bucuresti, Romania, 011025 Site 4407 Sibiu, Romania, 550166 Site 4401 Tg. Mures, Romania, 540139 Site 4406 Timisoara, Romania, 300594 Collapse <<
NCT01357837	Osteoarthritis of the Knee	Phase 2	Completed	-	Austria ... more >> Site 3604 Linz, Austria, 4021 Site 3605 Senftenberg, Austria, 3541 Site 3603 Wien, Austria, 1090 Site 3602 Wien, Austria, 1100 Site 3601 Wien, Austria, 1130 Poland Site 3203 Bialystok, Poland, 15-337 Site 3202 Elblag, Poland, 82-300 Site 3208 Gdynia, Poland, 81-834 Site 3206 Krakow, Poland, 30-349 Site 3207 Lublin, Poland, 20-605 Site 3210 Szczecin, Poland, 71-252 Site 3201 Torun, Poland, 87-100 Site 3204 Warsawa, Poland Site 3211 Warszawa, Poland, 02-730 Site 3213 Wloszczowa, Poland, 29-100 Site 3205 Wroclaw, Poland, 50-088 Spain Site 3305 Barcelona, Spain, 08028 Site 3302 Barcelona, Spain, 08034 Site 3303 Coruna, Spain, 15006 Site 3312 Málaga, Spain, 29009 Site 3308 Mérida.Badajoz., Spain, 06800 Site 3310 Oviedo, Spain, 33009 Site 3311 Petrer (Alicante), Spain, 03610 Site 3304 Santiago de Compostela, Spain, 15705 Site 3306 Sevilla, Spain, 41009 Site 3313 Torrelavega (Cantabria), Spain, 39300 Collapse <<
NCT03757559	Abuse, Drug	Phase 1	Completed	-	Canada, Ontario ... more >> INC Research Toronto, Ontario, Canada, M5V 2T3 Collapse <<
NCT02031432	Pain Neoplasm... more >>s Chronic Pain Collapse <<	Phase 3	Completed	-	Austria ... more >> AT004 Vienna, Austria, 1090 Belgium BE001 Sint-Niklaas, Belgium, 9100 Bulgaria BG001 Shumen, Bulgaria, 9700 BG008 Sofia, Bulgaria, 1330 BG003 Sofia, Bulgaria, 1407 BG004 Sofia, Bulgaria, 1407 Denmark DK006 Aalborg, Denmark, 9000 DK004 Herlev, Denmark, 2730 Germany DE008 Böhlen, Germany, 4564 DE010 Munich, Germany, 81377 Hungary HU011 Nyiregyhaza, Hungary, 4400 Poland PL012 Będzin, Poland, 42-500 PL014 Dąbrowa Górnicza, Poland, 41-300 PL003 Gdansk, Poland, 80-208 PL010 Gliwice, Poland, 44-100 Romania RO002 Cluj-Napoca, Romania, 400015 Serbia RS003 Belgrade, Serbia, 11000 RS002 Sremska Kamenica, Serbia, 21204 RS005 Zrenjanin, Serbia, 23000 Slovakia SK004 Bratislava, Slovakia, 851 07 SK001 Presov, Slovakia, 08001 SK005 Pruské, Slovakia, 018 52 Collapse <<
NCT01964378	Pain Neoplasm... more >>s Chronic Pain Collapse <<	Phase 3	Terminated(low accrual that ma... more >>de the study no longer feasible/ decision not related to safety and efficacy) Collapse <<	-	-
NCT01709214	Moderate to Severe Chronic Pai... more >>n Due to Osteoarthritis of the Knee Collapse <<	Phase 2	Completed	-	-
NCT01939366	Chronic Pain ... more >>Diabetic Neuropathies Diabetes Mellitus Collapse <<	Phase 2	Completed	-	-

Cebranopadol Catalog No. CSN13503

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