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CAS No.: 86329-79-5

Cefodizime sodium/头孢地嗪钠 Catalog No. CSN23260

Synonyms: Cefodizime disodium;HR-221;THR-221

Cefodizime disodium, the sodium salt form of cefodizime which is a third generation cephalosporin with antibacterial activity.

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生物活性

描述Cefodizime (Disodium) is a third generation cephalosporin with a broad spectrum of antibacterial activity. A single dose of cefodizime 1 or 2 g is also useful in treating lower urinary tract infections, particularly uncomplicated infections, with a rate of clinical success of 72 to 88%. Urogenital gonorrhoea, whether caused by beta-lactamase producing or non-beta-lactamase producing Neisseria gonorrhoeae, is very effectively treated by single dose therapy with intramuscular cefodizime 0.25 to 1 g (virtually 100% cured) ^[1]. For Enterobacteriaceae, MIC50s and MIC90s of cefodizime (mg/l), respectively, were as follows, for naturally non-beta-lactamase-producing species: Escherichia coli 0.12 and 0.5, Salmonella spp. and Shigella spp. 0.25 and 0.5, Proteus mirabilis 0.016 and 0.03; for chromosomal penicillinase-producing species. Klebsiella spp. 0.25 and 64, and for chromosomal cephalosporinase-producing species. Enterobacter cloacae 1 and 64, Citrobacter freundii 1 and 128, Serratia marcescens 2 and 8: indole-positive Proteus spp. 0.06 and 0.5; and Providencia stuartii 0.5 and 1. The activity of cefodizime was not modified by plasmid-mediated penicillinase-producing strains but cefodizime was inactive against cephalosporinase hyper-producing strains and against expanded broad-spectrum beta-lactamase-producing strains. Cefodizime was noticeably less active against Pseudomonas aeruginosa and Acinetobacter baumannii with MICs ranging from 32 to more than 128 mg/l. Haemophilus spp. and Neisseria gonorrhoeae, regardless of beta-lactamase producing status, as well as N. meningitidis, were highly susceptible (MIC50s and MIC90s less than or equal to 0.008 mg/l). Cefodizime was moderately active against methicillin-susceptible staphylococci (MIC50 and MIC90 8 mg/l) but failed to inhibit methicillin-resistant strains. Enterococci were generally resistant: Streptococcus pyogenes and Str. pneumoniae were inhibited by low concentrations (MIC50 and MIC90 0.12 and 0.5 mg/l). A fairly wide range of MICs was found for anaerobes, with lower values for Clostridium perfringens (MIC50 and MIC90 0.5 and 1 mg/l) than for Bacteroides fragilis (8- greater than 128 mg/l) ^[2]. Cefodizime did not induce in vitro resistance of Staphylococcus aureus or Escherichia coli. Because of its binding properties to PBPs 1A/B and 3, cefodizime leads to filamentation of Gram-negative rods and, at only slightly higher concentrations, to bacteriolysis^[3].
参考文献

[1] Barradell LB, Brogden RN. Cefodizime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use [published correction appears in Drugs 1993 Jan;45(1):130]. Drugs. 1992;44(5):800‐834
[2] Soussy CJ, Chanal M, Kitzis MD. The in-vitro activity of cefodizime: a review. J Antimicrob Chemother. 1990;26 Suppl C:13‐21
[3] Limbert M, Klesel N, Seeger K, Seibert G, Winkler I, Schrinner E. Cefodizime, an aminothiazolylcephalosporin. I. In vitro activity. J Antibiot (Tokyo). 1984;37(8):892‐900

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5908 mL
- 7.9538 mL
- 15.9075 mL
- 5 mM
- 0.3182 mL
- 1.5908 mL
- 3.1815 mL
- 10 mM
- 0.1591 mL
- 0.7954 mL
- 1.5908 mL

技术信息

CAS号

86329-79-5

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H18N6Na2O7S4

运输

蓝冰

分子量

628.63

别名

Cefodizime disodium;HR-221;THR-221;头孢地嗪钠;头孢地嗪二钠

溶解度

DMSO	130.0 mg/mL (206.8 mM)
Water	155.0 mg/mL (246.6 mM)

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