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CAS No.: 61270-78-8

Cefonicid sodium/头孢尼西钠 Catalog No. CSN10574

Synonyms: Monocid sodium;Cefonicid Disodium Salt;Cefonicid (sodium salt)

Cefonicid sodium is a cephalosporin antibiotic, interfering with cell wall biosynthesis in bacteria, leading to lysis of the infectious organism.

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实验方案

技术信息

生物活性

描述Cefonicid sodium is less active than other currently available first- and second-generation cephalosporins against gram-positive cocci, particularly Staphylococcus. Despite a small volume of distribution and high protein binding, cefonicid achieves high tissue concentrations. Cefonicid is usually well tolerated. In treating skin infections, cefonicid was usually less effective than cefazolin against Staphylococcus aureus. In genitourinary infections, cefonicid 1 g daily (as the sodium salt) in a single dose has shown comparable efficacy to cefamandole or amoxicillin given in multiple daily doses^[2]. Moreover, Cefonicid was a non-competitive inhibitor [Ki of 0.8 x 10(-6)M) of cephalothin hydrolysis by the Type I enzyme^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... more >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD Collapse <<

参考文献

[1] Bloom JC, Lewis HB, et al. The hematologic effects of cefonicid and cefazedone in the dog: a potential model of cephalosporin hematotoxicity in man. Toxicol Appl Pharmacol. 1987 Aug;90(1):135-42.
[2] Dudley MN, Quintiliani R, Nightingale CH. Review of cefonicid, a long-acting cephalosporin. Clin Pharm. 1984 Jan-Feb;3(1):23-32.
[3] Mehta RJ, Newman DJ, Bowie BA, Nash CH 3rd, Actor P. Cefonicid: a stable beta-lactamase inhibitor. J Antibiot (Tokyo). 1981 Feb;34(2):202-5.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7049 mL
- 8.5247 mL
- 17.0494 mL
- 5 mM
- 0.3410 mL
- 1.7049 mL
- 3.4099 mL
- 10 mM
- 0.1705 mL
- 0.8525 mL
- 1.7049 mL

技术信息

CAS号

61270-78-8

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H16N6Na2O8S3

运输

蓝冰

分子量

586.53

别名

Monocid sodium;Cefonicid Disodium Salt;Cefonicid (sodium salt);Monocid;Cefonicid Sodium;SK&F D-75073-Z2;UNII-F74MFL78A1;CHEBI:3492;SKF-75073-2;Cefonicid;Sodium;头孢尼西钠

溶解度

DMSO	99.0 mg/mL (168.8 mM)
Water	98.0 mg/mL (167.1 mM)
Ethanol	Insoluble

动物实验配方

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Cefonicid sodium/头孢尼西钠 Catalog No. CSN10574

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