|1-((6R,7R)-7-((Z)-2-(2-氨基噻唑-4-基)-2-(甲氧基亚氨基)乙酰胺基)-2-羧基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-3-基)甲基)-5,6,7,8-四氢喹啉-1-硫酸氢铵|CsnPharm

CAS No.: 118443-89-3

Cefquinome Sulfate/硫酸头孢喹诺 Catalog No. CSN10584

Synonyms: Cefquinome (sulfate);HR 111V sulfate;Cefquinome Sulfate

Cefquinome Sulfate is an antibacterial used in the treatment of infections caused by pathogens such as S. aureus, E. coli, Streptococcus, P. multocida and A. pleuropneumoniae.

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技术信息

生物活性

描述Cefquinome Sulfate (CS) is a fourth-generation cephalosporin, which has been developed solely for veterinary use^[3]. Cefquinome inhibited members of the Enterobacteriaceae at less than or equal to 0.5 microgram/ml for Escherichia coli, Klebsiella pneumoniae, K. oxytoca, Citrobacter diversus, Salmonella Shigella, Proteus mirabilis, Morganella, and Providencia. Overall, the in vitro activity of cefquinome was comparable with aminothiazolyl cephalosporins. It inhibited some Enterobacter and Citrobacter freundii resistant to ceftazidime as did cefpirome and cefepime^[4]. Cefquinome (88.8mg cefquinome sulphate per 8mL) was administered by the intramammary route to all quarters and/or "systemically" via the perfusion fluid at concentrations similar to those measured in plasma following intramuscular administration of 1mg cefquinome per kg body weight. For the treatment of acute mastitis a combination of both intramammary and systemic administration is likely to be advantageous in order to rapidly produce maximum cefquinome concentrations in all regions of the udder^[5]. Lower doses of cefquinome can be administered as aerosols providing high local drug concentrations in lung, but additional optimization of formulation is needed to improve distribution and persistence in lung^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5957 mL
- 7.9785 mL
- 15.9570 mL
- 5 mM
- 0.3191 mL
- 1.5957 mL
- 3.1914 mL
- 10 mM
- 0.1596 mL
- 0.7979 mL
- 1.5957 mL

技术信息

CAS号

118443-89-3

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H26N6O9S3

运输

蓝冰

分子量

626.68

别名

Cefquinome (sulfate);HR 111V sulfate;Cefquinome Sulfate;硫酸头孢喹肟;头孢喹诺硫酸盐

溶解度

DMSO	99.0 mg/mL (158.0 mM)
Ethanol	Insoluble

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