|2-氨基-9-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-9-(6-氨基-9H-嘌呤-9-基)-3,5,10,12-四羟基-5,12-dioxidooctahydro-2H,7H-二呋喃[3,2-d:3',2'-j][1,3,7,9]四氧杂[2,8]二磷酸环十二烯-2-基)-3,9-二氢-6H-嘌呤-6-酮|CsnPharm

CAS No.: 849214-04-6

cGAMP Catalog No. CSN18467

Synonyms: Cyclic GMP-AMP;3',3'-cGAMP;Cyclic AMP-GMP

cGAMP, an endogenous second messenger, can induce the formation of cytokines and promote innate immune response. It also acts as an activator of STING with antitumor activity.

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技术信息

生物活性

描述cGAMP (cyclic-GMP-AMP) functions as an endogenous second messenger that triggers interferon production in response to cytosolic DNA. It is a STING ligand which binds to STING, leading to the activation of IRF3 and induction of interferon-β^[4]. cGAS-synthesized cGAMP is transferred from producing cells to neighbouring cells through gap junctions, where it promotes STING activation and thus antiviral immunity independently of type I IFN signaling, identifying cGAS-triggered cGAMP transfer as a novel host strategy that serves to rapidly convey antiviral immunity in a transcription-independent, horizontal manner^[5]. On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1^[6].
动物研究
剂量
Mice: 0.5 mg/kg - 20 mg/kg^[4] (p.o.)

给药途径
p.o.
临床研究

动物研究
剂量	Mice: 0.5 mg/kg - 20 mg/kg^[4] (p.o.)
给药途径	p.o.

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02986867	Urothelial Carcinoma ... more >> Melanoma Cervical Carcinoma in Situ Collapse <<	Not Applicable	Recruiting	December 2020	United States, Texas ... more >> University of Texas Southwestern Medical Center Recruiting Dallas, Texas, United States, 75063 Contact: Pamela Kurian 214-648-5874 pamela.kurian@utsouthwestern.edu Principal Investigator: Yull Arriaga, MD Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.4828 mL
- 7.4139 mL
- 14.8277 mL
- 5 mM
- 0.2966 mL
- 1.4828 mL
- 2.9655 mL
- 10 mM
- 0.1483 mL
- 0.7414 mL
- 1.4828 mL

技术信息

CAS号

849214-04-6

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H24N10O13P2

运输

蓝冰

分子量

674.41

别名

Cyclic GMP-AMP;3',3'-cGAMP;Cyclic AMP-GMP;c-GMP-AMP

溶解度

Water

57.5 mg/mL

动物实验配方

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