|3-(2,4-二氯苯基)-3-氧代-2-(4-氧代-3,4-二氢喹唑啉-2(1H)-亚基)丙腈|CsnPharm

CAS No.: 302803-72-1

Ciliobrevin A Catalog No. CSN19162

Synonyms: HPI-4;Hedgehog Pathway Inhibitor 4;HPI4. Hedgehog Pathway Inhibitor 4

Ciliobrevin A inhibits hedgehog (Hh) signaling pathway with IC50 less than 10 μM.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens^[3]. Ciliobrevin A is an Hh signaling pathway inhibitor with an IC₅₀ value less than 10 μM^[4]. Ciliobrevin A prevents an increase in the FLAG-Gli2 full-length/repressor ratio upon Shh stimulation. Ciliobrevin A also perturbs primary cilia formation in the Shh-LIGHT2_FLAG-Gli1 cells and promotes accumulation of FLAG-Gli1 at the distal tip of this organelle. Ciliobrevin A significantly inhibits the proliferation of these neuronal progenitors, as measured by histone H3 phosphorylation (pH3) levels, and reduces cellular levels of cyclin D1 protein and Gli1, Gli2, and N-Myc transcripts in the CGNPs^[4]. Furthermore, HPI-4 could distinctly disturb HH pathway-mediated ciliogenesis and suppress primary cilia-related protein intraflagellar transport protein IFT88 expression. Hh downstream effect molecular GLI2 was restrained to block parathyroid hormone-related protein and affect MAPK/ERK-regulated matrix metalloproteinases (MMP2 and MMP9)^[5]. In zebrafish models, HPI-4 can effectively prevent pancreatic fibrosis and destruction^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7919 mL
- 13.9595 mL
- 27.9191 mL
- 5 mM
- 0.5584 mL
- 2.7919 mL
- 5.5838 mL
- 10 mM
- 0.2792 mL
- 1.3960 mL
- 2.7919 mL

技术信息

CAS号

302803-72-1

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H9Cl2N3O2

运输

蓝冰

分子量

358.18

别名

HPI-4;Hedgehog Pathway Inhibitor 4;HPI4. Hedgehog Pathway Inhibitor 4

溶解度

DMSO	160.0 mg/mL (446.7 mM)
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Ciliobrevin A Catalog No. CSN19162

靶点选择性

请登录您的专属账户

确认信息