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CAS No.: 637-07-0

Clofibrate/氯贝特 Catalog No. CSN11481

Synonyms: ICI 28257;NSC 79389;Ethyl clofibrate

Clofibrate, a fibric acid derivative, is a selective agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50 of 50 µM. Clofibrate has been used to treat hyperlipoproteinemia type III and severe hypertriglyceridemia.

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生物活性

描述Clofibrate, a fibric acid derivative, is a selective agonist of PPARα with EC50 of 50 µM. Clofibrate has been used to treat hyperlipoproteinemia type III and severe hypertriglyceridemia^[3]. Clofibrate (0.5, 1, 2 mM) increases FABP1 expression in two fatty acid (FA)-treated rat hepatoma cells. Clofibrate lowers ROS levels after early treatment, much more than late treatment in FA-treated cells^[4]. Moreover, clofibrate administration to 7 days MI-rats exerts an antioxidant, pro-vasodilator expression profile, and anti-fibrotic effect suggesting that PPARα activation can be considered a therapeutic target to improve cardiac condition posterior to ischemia^[5]. Giving CF (0.5% Clofibrate) to pregnant mice programmed greater HFD(high-fat diet)-induced WAT (white adipose tissue) browning in subcutaneous, but not in visceral fat, in their male offspring at adulthood^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03031821	Prostate Cancer ... more >> Metabolic Syndrome Collapse <<	Phase 3	Not yet recruiting	June 1, 2023	Canada, British Columbia ... more >> BC Cancer Agency - Vancouver Cancer Centre Not yet recruiting Vancouver, British Columbia, Canada, V5Z 4E6 Contact: Bernie Eigl, MD 604-877-6000 bernie.eigl@bccancer.bc.ca Principal Investigator: Bernie Eigl, MD Collapse <<
NCT00000483	Cardiovascular Diseases ... more >> Coronary Disease Heart Diseases Myocardial Infarction Myocardial Ischemia Collapse <<	Not Applicable	Completed	-	-
NCT00000482	Cardiovascular Diseases ... more >> Coronary Disease Heart Diseases Myocardial Infarction Myocardial Ischemia Collapse <<	Phase 3	Completed	-	-

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.1203 mL
- 20.6017 mL
- 41.2034 mL
- 5 mM
- 0.8241 mL
- 4.1203 mL
- 8.2407 mL
- 10 mM
- 0.4120 mL
- 2.0602 mL
- 4.1203 mL

技术信息

CAS号

637-07-0

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H15ClO3

运输

蓝冰

分子量

242.70

别名

ICI 28257;NSC 79389;Ethyl clofibrate;Atromid-S;Clofibrato;Clofibratum;氯贝丁酯

溶解度

DMSO	99.0 mg/mL (407.9 mM)
Water	Insoluble

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Clofibrate/氯贝特 Catalog No. CSN11481

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