|5-氯-8-羟基喹啉|CsnPharm

CAS No.: 130-16-5

Cloxiquine/5-氯-8-羟基喹啉 Catalog No. CSN12522

Synonyms: 5-Chloro-8-quinolinol;Dermofungin;5-Chloroquinolin-8-Ol

Cloxiquine is a quinolinol derivative with property of antibacterial, antifungal, antiaging and antituberculosis.

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技术信息

生物活性

描述Cloxiquine (CLQ), a traditional antituberculosic drug, exhibited strong inhibitory effects on the growth and metastasis of melanoma cells both in vivo and in vitro. In contrast, CLQ at the tested doses did not show any apparent toxicity in normal melanocytes and in the liver. At the metabolic level, treatment with CLQ decreased glycolysis, thus potentially inhibiting the "Warburg effect" in B16F10 cells. More importantly, combination of CLQ and 2-deoxyglucose (2-DG), a well-known glycolysis inhibitor, did not show a synergistic effect on the tumor growth and metastasis, indicating that inhibition of glycolysis is potentially involved in mediating CLQ's anti-melanoma function^[2].
参考文献

[1] Latosinska JN, Latosinska M, et al. Supramolecular synthon pattern in solid clioquinol and cloxiquine (APIs of antibacterial, antifungal, antiaging and antituberculosis drugs) studied by ³⁵Cl NQR, ¹H-¹⁷O and ¹H-¹⁴N NQDR and DFT/QTAIM. J Mol Model. 2011 Jul;17(7):1781-800.
[2] Zhang W, Shao W, Dong Z, Zhang S, Liu C, Chen S. Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ. Cell Death Dis. 2019;10(6):404. Published 2019 May 28

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.5678 mL
- 27.8392 mL
- 55.6784 mL
- 5 mM
- 1.1136 mL
- 5.5678 mL
- 11.1357 mL
- 10 mM
- 0.5568 mL
- 2.7839 mL
- 5.5678 mL

技术信息

CAS号

130-16-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H6ClNO

运输

蓝冰

分子量

179.60

别名

5-Chloro-8-quinolinol;Dermofungin;5-Chloroquinolin-8-Ol;5CHQ;Cloxyquin;NSC-35083;5-氯-8-羟基喹啉

溶解度

DMSO	33.0 mg/mL (183.7 mM)
Water	Insoluble
Ethanol	34.0 mg/mL (189.3 mM)

动物实验配方

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Cloxiquine/5-氯-8-羟基喹啉 Catalog No. CSN12522

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