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CAS No.: 135463-81-9

Coluracetam/考拉西坦 Catalog No. CSN12675

Synonyms: MKC-231;BCI 540;考拉西坦

Coluracetam a nootropic which can increase the potency of AMPA receptors.

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纯度 & 质量文件批次:

靶点选择性

生物活性

描述Coluracetam (MKC-231) a new choline uptake enhancer. MKC-231(10(-10)-10(-6) moll) significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. Oral administration of MKC-231 (1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats^[3]. MKC-231 improved the AF64A-induced working memory deficit and hippocampal ACh(acetylcholine) depletion, probably by recovering reduced high-affinity choline uptake and ACh release^[4].
参考文献

[1] Dutta A, McKie S, Deakin JF. Ketamine and other potential glutamate antidepressants. Psychiatry Res. 2015 Jan 30;225(1-2):1-13.
[2] Murai S, Saito H, et al. MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. J Neural Transm Gen Sect. 1994;98(1):1-13.
[3] Bessho T, Takashina K, Tabata R, Ohshima C, Chaki H, Yamabe H, Egawa M, Tobe A, Saito K. Effect of the novel high affinity choline uptake enhancer 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b] quinolin-4-yl)acetoamide on deficits of water maze learning in rats. Arzneimittelforschung. 1996 Apr;46(4):369-73. PMID: 8740080.
[4] Murai S, Saito H, Abe E, Masuda Y, Odashima J, Itoh T. MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. J Neural Transm Gen Sect. 1994;98(1):1-13. doi: 10.1007/BF01277590. PMID: 7710736.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9291 mL
- 14.6454 mL
- 29.2908 mL
- 5 mM
- 0.5858 mL
- 2.9291 mL
- 5.8582 mL
- 10 mM
- 0.2929 mL
- 1.4645 mL
- 2.9291 mL

技术信息

CAS号

135463-81-9

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H23N3O3

运输

蓝冰

分子量

341.40

别名

MKC-231;BCI 540;考拉西坦

溶解度

DMSO	67.0 mg/mL (196.2 mM)
Water	Insoluble
Ethanol	22.0 mg/mL (64.4 mM)

动物实验配方

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总药量计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 动物数量只每天给药次给药天

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工作液计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 给药体积μL

您需要配制的工作液浓度为：mg/mL

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