|rel-(1R,2R,3S,4S,5R,6S)-7-氧杂二环[4.1.0]庚烷-2,3,4,5-四醇|CsnPharm

CAS No.: 6090-95-5

Conduritol B epoxide/环己烯四醇β环氧化物 Catalog No. CSN10691

Synonyms: Conduritol B Epoxide;D,L-1,2-Anhydro-myo-inositol;Activity: Inhibits alpha-glucosidase activity

Conduritol B epoxide is an irreversible inhibitor of acid β-glucosidase (GCase) with IC50 of 1 μM.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Neuronopathic Gaucher disease is caused by mutations in GBA1 that encodes lysosomal acid β-glucosidase (GCase) that has glucosylceramide (GC) and its un-acylated form, glucosylsphingosine (GS) as substrates. Conduritol B epoxide (CBE) is an irreversible covalently bound GCase inhibitor. Differentiated N2a cells treated with CBE resulted in significant GC and GS accumulation in CBE-N2a cells, thereby creating a nGD model. CBE-N2a cells had higher calcium levels than in N2a cells without caffeine at baseline and higher cytosolic calcium levels compared to N2a cells. CBE-N2a cells showed a significant reduction in OCR (oxygen consumption rate) as evidenced by rate of ATP production, basal respiration and maximal respiration, compared to N2a cells, indicating reduced mitochondrial function in this nGD cell model^[2]. In vivo, long-term daily CBE treatment (100 mg/kg) of 4L mice led to hind limb paralysis and small amounts of α-synuclein accumulation in the olfactory bulb and brainstem^[3].
参考文献

[1] Liou B, Peng Y, et al. Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. Hum Mol Genet. 2016 Dec 1;25(23):5126-5141.
[2] Liou B, Peng Y, Li R, Inskeep V, Zhang W, Quinn B, Dasgupta N, Blackwood R, Setchell KD, Fleming S, Grabowski GA, Marshall J, Sun Y. Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. Hum Mol Genet. 2016 Dec 1;25(23):5126-5141
[3] Xu YH, Sun Y, Ran H, Quinn B, Witte D, Grabowski GA. Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models. Mol Genet Metab. 2011 Apr;102(4):436-47

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.1675 mL
- 30.8374 mL
- 61.6749 mL
- 5 mM
- 1.2335 mL
- 6.1675 mL
- 12.3350 mL
- 10 mM
- 0.6167 mL
- 3.0837 mL
- 6.1675 mL

技术信息

CAS号

6090-95-5

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C6H10O5

运输

蓝冰

分子量

162.14

别名

Conduritol B Epoxide;D,L-1,2-Anhydro-myo-inositol;Activity: Inhibits alpha-glucosidase activity;specific inhibitor of glucocerebrosidase in cultured cells;CBE

溶解度

DMSO	195.0 mg/mL (1202.7 mM)
Water	140.0 mg/mL (863.4 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Conduritol B epoxide/环己烯四醇β环氧化物 Catalog No. CSN10691

靶点选择性

请登录您的专属账户

确认信息