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CAS No.: 18080-67-6

Conoidin A Catalog No. CSN27840

Conoidin A inactivates peroxiredoxins by covalently binding to the catalytic cysteine, with IC50 value of 23µM in the parasite T. gondii and peroxiredoxin I in the hookworm A. ceylanicum.

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技术信息

生物活性

描述Conoidin A is an inhibitor of host cell invasion by the protozoan parasite Toxoplasma gondii^[3]. Inhibition of PRDXs by conoidin A (1, 10, or 100 µM) significantly decreased the oxidized form of peroxiredoxins (PRDXs-SO3) in spermatozoa^[4]. Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease. Conoidin A (intraperitoneal injection; 5 mg/kg; for three successive days before MI/R injury) blocks the effect of Luteolin (HY-N0162) on the ST‐segment elevation. Furthermore, an increase in the infarct size presented of the MI/R (myocardial ischaemia/reperfusion) group can be reduced by Luteolin. But pre‐treatment with conoidin A abolishes the effect of Luteolin. Pre‐treatment with conoidin A also prevents Luteolin-reduced activities of CK‐MB, AST and LDH in vivo^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8736 mL
- 14.3682 mL
- 28.7364 mL
- 5 mM
- 0.5747 mL
- 2.8736 mL
- 5.7473 mL
- 10 mM
- 0.2874 mL
- 1.4368 mL
- 2.8736 mL

技术信息

CAS号	18080-67-6	储存条件	粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C10H8Br2N2O2	运输	蓝冰
分子量	347.99	别名

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Conoidin A Catalog No. CSN27840

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