|(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-四甲基十六碳-2,4,6,8,10,12,14-七烯二酸|CsnPharm

CAS No.: 27876-94-4

Crocetin/藏红花酸 Catalog No. CSN20383

Synonyms: trans-Crocetin;NSC 407300;Crotecin

Crocetin, a saffron derivative, is an inhibitor of human lactate dehydrogenase 5 in the antiglycolytic approach against cancer.

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生物活性

描述Crocetin is an active constituent of saffron (Crocus sativus L.) stigma and exhibits various health-promoting properties including anti-tumor, neuroprotective effects, anti-diabetics, anti-inflammatory, anti-hyperlipidemia, etc^[3]. Crocetin could be suggested as a potential dermatological whitening agent in skin care products. Decreased tyrosinase activity, melanin content, tyrosinase and MITF (Microphthalmia-Associated Transcription Factor) proteins levels, and ROS (Reactive Oxygen Species) production showed the inhibition of melanogenesis in B16F10 cells by crocetin^[4]. Human Umbilical Vein Endothelial Cells (HUVECs) were incubated with various concentrations of Crocetin (1, 5, 25, 50, and 100 µM) over a period of 72 h. Protein level of VEGFR-1, -2 and p-Akt/Akt, p-eNOS/eNOS ratios were increased 72 h after the treatment of HUVECs with Crocetin. Crocetin promotes HUVECs angiogenesis potential by the modulation of VEGF signaling pathway and increased cell viability^[5]. Crocetin significantly inhibited the proliferation of KYSE-150 cells in a dose- and time-dependent manner. Crocetin also markedly induced cell apoptosis. Furthermore, we have found that crocetin not only inhibited the activation of PI3K/AKT, extracellular signal-regulated kinase-1/2 (ERK1/2), and p38 but also upregulated the p53/p21 levelhttps://pubmed.ncbi.nlm.nih.gov/30783055.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01278277	Retinal Degeneration ... more >> Genetic Disease Single-Gene Defects Macular Dystrophy Collapse <<	Phase 1 Phase 2	Active, not recruiting	December 2017	Italy ... more >> Policlinico A. Gemelli Rome, Italy, 00168 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0450 mL
- 15.2252 mL
- 30.4505 mL
- 5 mM
- 0.6090 mL
- 3.0450 mL
- 6.0901 mL
- 10 mM
- 0.3045 mL
- 1.5225 mL
- 3.0450 mL

技术信息

CAS号

27876-94-4

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H24O4

运输

蓝冰

分子量

328.40

别名

trans-Crocetin;NSC 407300;Crotecin;TSC;Natural Yellow 6;8,8'-Diapocarotenedioic acid. ,8'-Diapo-psi,psi-carotenedioic acid;藏红花酸;藏红花素

溶解度

DMSO	1.0 mg/mL (3.0 mM)

动物实验配方

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