|(2,3-二氢苯并[b][1,4]二氧杂环己烷基-6-基)(哌啶-1-基)甲酮|CsnPharm

CAS No.: 215923-54-9

CX546 Catalog No. CSN12690

Synonyms: UNII-PV6YEC8983;GR-87;BDP-17

CX-546 is a AMPAR potentiator which can destabilize the desensitized receptor conformation.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent. Intraperitoneal injections of CX546 increased hippocampal BDNF (brain-derived neurotrophic factor) mRNA levels in aged rats and middle-aged mice^[3]. Administration of the positive modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors (AMPAR), CX546, during the conditioning phase only, improved the disrupted LI in mGluR5 knockout mice and facilitated LI in control C57BL/6J mice, given extended number of conditioning trails. PPI (Prepulse inhibition) deficit of mGluR5(-/-) mice was effectively reversed by CX546, whereas aniracetam had a less pronounced effect^[4]. In binding tests, CX546 caused an approximately 2-fold increase in the affinity for radiolabeled agonists, whereas CX516 was ineffective^[5]. CX546 reduced the degree of desensitization more potently than CX516 or IDRA 21, but not as efficiently as cyclothiazide. CX546 increased agonist affinity threefold on nondesensitizing AMPA receptors by slowing agonist unbinding. In the presence of CX546, the current induced by short pulses of glutamate from recombinant GluR2 receptors decayed with a time course that was approximately twentyfold faster than EPSCs^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.0438 mL
- 20.2192 mL
- 40.4384 mL
- 5 mM
- 0.8088 mL
- 4.0438 mL
- 8.0877 mL
- 10 mM
- 0.4044 mL
- 2.0219 mL
- 4.0438 mL

技术信息

CAS号

215923-54-9

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H17NO3

运输

蓝冰

分子量

247.29

别名

UNII-PV6YEC8983;GR-87;BDP-17

溶解度

DMSO	360.0 mg/mL (1455.8 mM)
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

CX546 Catalog No. CSN12690

靶点选择性

请登录您的专属账户

确认信息