|(2S,3R,E)-2-氨基十八碳-4-烯-1,3-二醇|CsnPharm

CAS No.: 123-78-4

D-Sphingosine/D-鞘氨醇 Catalog No. CSN26161

Synonyms: Erythrosphingosine;erythro-C18-Sphingosine;trans-4-Sphingenine

D-Sphingosine inhibits protein kinase C.

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技术信息

生物活性

描述Protein kinase C, a family of related serine/threonine kinases implicated in multiple signal transduction pathways, exhibits antitumor property in mammalian cells. D-erythro-Sphingosine is a PKC inhibitor with an EC50 value of 8 ± 3 μM for p32. Treatment of Jurkat T cells with D-erythro-Sphingosine led to a ~4-fold increase in p32 phosphorylation, with the maximal effect observed at 10 μM^[1]. D-erythro-Sphingosine is also a PP2A agonist that activates PP2A in neuronal cultures at a concentration of 10 nM. Rats treated with D-erythro-Sphingosine (1 μM) showed a higher locomotor BBB score after spinal cord injury compared to the vehicle-treated control group^[2].
参考文献

[1] Pushkareva MYu, Bielawska A, Menaldiv D, Liotta D, Hannun YA. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15;294 (Pt 3)(Pt 3):699-703. doi: 10.1042/bj2940699
[2] Cheng P, Chen K, Yu W, Gao S, Hu S, Sun X, Huang H. Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS. J Neurol Sci. 2015 Dec 15;359(1-2):48-56. doi: 10.1016/j.jns.2015.10.025

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3390 mL
- 16.6949 mL
- 33.3899 mL
- 5 mM
- 0.6678 mL
- 3.3390 mL
- 6.6780 mL
- 10 mM
- 0.3339 mL
- 1.6695 mL
- 3.3390 mL

技术信息

CAS号

123-78-4

储存条件

粉末: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H37NO2

运输

蓝冰

分子量

299.49

别名

Erythrosphingosine;erythro-C18-Sphingosine;trans-4-Sphingenine;(2S,3R)-D-erythro-2-amino-1,3-Octadec-4E-enediol;Sphingosine;C18 chain;(−)-Sphingosine;Sphingosine (d18:1);D-Sphingosine;鞘氨醇;D-赤型鞘氨醇

溶解度

DMSO	40.0 mg/mL (133.6 mM) warming

动物实验配方

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