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CAS No.: 404951-53-7
Synonyms: NVP-LAQ824;LAQ824;达诺司他
Dacinostat is a HDAC inhibitor with IC50 of 32 nM which can activate the p21 promoter.
生物活性
靶点 | HDAC IC50:32nM |
实验方案
技术信息
CAS号 | 404951-53-7 | 储存条件 |
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分子式 | C22H25N3O3 | 运输 | 蓝冰 | |||||||||||
分子量 | 379.45 | 别名 | NVP-LAQ824;LAQ824;达诺司他 | |||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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786-0 cells | - | Proliferation assay | - | Antiproliferative activity against human 786-0 cells by SRB assay, GI50=2.38 μM | 21621883 |
A498 cells | - | Proliferation assay | - | Antiproliferative activity against human A498 cells by SRB assay, GI50=1.11 μM | 21621883 |
A498 cells | - | Cytotoxicity assay | - | Cytotoxicity against human A498 cells, LC50=5.88 μM | 21621883 |
A549 cells | - | Proliferation assay | - | Antiproliferative activity against human A549 cells by SRB assay, GI50=1.09 μM | 21621883 |
ACHN cells | - | Proliferation assay | - | Antiproliferative activity against human ACHN cells by SRB assay, GI50=1.1 μM | 21621883 |
BT549 cells | - | Proliferation assay | - | Antiproliferative activity against human BT549 cells by SRB assay, GI50=6.04 μM | 21621883 |
Caki1 cells | - | Proliferation assay | - | Antiproliferative activity against human Caki1 cells by SRB assay, GI50=0.619 μM | 21621883 |
Caki1 cells | - | Cytotoxicity assay | - | Cytotoxicity against human Caki1 cells, LC50=5.79 μM | 21621883 |
CCRF-CEM cells | - | Proliferation assay | - | Antiproliferative activity against human CCRF-CEM cells by SRB assay, GI50=0.251 μM | 21621883 |
CHO cells | - | Function assay | - | Inhibition of human ERG expressed in CHO cells by automated patch clamp electrophysiology assay, IC50=12.2 μM | 20205394 |
COLO205 cells | - | Proliferation assay | - | Antiproliferative activity against human COLO205 cells by SRB assay, GI50=1.08 μM | 21621883 |
DU145 cells | - | Proliferation assay | - | Antiproliferative activity against human DU145 cells by SRB assay, GI50=29.9 μM | 21621883 |
EKVX cells | - | Proliferation assay | - | Antiproliferative activity against human EKVX cells by SRB assay, GI50=1.75 μM | 21621883 |
H1299 | - | Growth inhibition assay | - | Inhibitory activity against H1299 human lung carcinoma cell growth, IC50=0.15 μM | 14521422 |
H1299 cells | - | Proliferation assay | - | Antiproliferative activity against human H1299 cells by MTS assay, IC50=0.161 μM | 20205394 |
H1299 cells | - | Proliferation assay | - | Antiproliferative activity against human H1299 cells, IC50=0.1 μM | 21650221 |
H460 cells | - | Growth inhibition assay | 48 h | Growth inhibition of human H460 cells after 48 hrs by SRB assay, IC50=0.07 μM | 21073160 |
HCT116 | - | Growth inhibition assay | - | Inhibitory activity against HCT116 human colon cell growth, IC50=0.01 μM | 14521422 |
HCT116 | - | Cytotoxicity assay | - | Cytotoxicity against human HCT116 cells by MTT assay, IC50=0.05 μM | 17941625 |
HCT116 cells | - | Proliferation assay | - | Antiproliferative activity against human HCT116 cells by MTS assay, IC50=0.013 μM | 20205394 |
HCT116 cells | - | Growth inhibition assay | 48 h | Growth inhibition of human HCT116 cells after 48 hrs by SRB assay, IC50=0.018 μM | 21073160 |
HCT116 cells | - | Proliferation assay | - | Antiproliferative activity against human HCT116 cells by SRB assay, GI50=0.347 μM | 21621883 |
HCT116 cells | - | Proliferation assay | - | Antiproliferative activity against human HCT116 cells, IC50=0.019 μM | 21742496 |
HCT116 cells | - | Proliferation assay | - | Antiproliferative activity against human HCT116 cells assessed as growth inhibition, IC50=0.019 μM | 21650221 |
HCT116 cells | - | Proliferation assay | - | Inhibitory concentration against HCT116 cells proliferation, IC50=0.01 μM | 14613312 |
HCT15 cells | - | Proliferation assay | - | Antiproliferative activity against human HCT15 cells by SRB assay, GI50=2.07 μM | 21621883 |
HEK293 cells | - | Function assay | - | Inhibition of HDAC1 in HEK293 cells, IC50=0.0026 μM | 18308563 |
HeLa cells | 0.3 μM | Function assay | 16 h | Inhibition of HDAC4-mediated repression of MEF2-dependent transcription in HeLa cells at 0.3 uM after 16 hrs by luciferase reporter gene assay | 17956988 |
HL-60(TB) cells | - | Proliferation assay | - | Antiproliferative activity against human HL-60(TB) cells by SRB assay, GI50=0.249 μM | 21621883 |
HOP62 cells | - | Proliferation assay | - | Antiproliferative activity against human HOP62 cells by SRB assay, GI50=0.502 μM | 21621883 |
HOP92 cells | - | Proliferation assay | - | Antiproliferative activity against human HOP92 cells by SRB assay, GI50=0.199 μM | 21621883 |
Hs 578T cells | - | Proliferation assay | - | Antiproliferative activity against human Hs 578T cells by SRB assay, GI50=5.82 μM | 21621883 |
HT-29 cells | - | Proliferation assay | - | Antiproliferative activity against human HT-29 cells by SRB assay, GI50=0.566 μM | 21621883 |
human mammary epithelial cells | - | Cytotoxicity assay | - | Cytotoxicity against human mammary epithelial cells by MTT assay, IC50=1 μM | 17941625 |
IGROV1 cells | - | Proliferation assay | - | Antiproliferative activity against human IGROV1 cells by SRB assay, GI50=0.187 μM | 21621883 |
IGROV1 cells | - | Cytotoxicity assay | - | Cytotoxicity against human IGROV1 cells, LC50=48.9 μM | 21621883 |
K562 cells | - | Proliferation assay | - | Antiproliferative activity against human K562 cells by SRB assay, GI50=0.55 μM | 21621883 |
KM12 cells | - | Proliferation assay | - | Antiproliferative activity against human KM12 cells by SRB assay, GI50=1.04 μM | 21621883 |
KM12 cells | - | Cytotoxicity assay | - | Cytotoxicity against human KM12 cells, LC50=29.9 μM | 21621883 |
LOXIMVI cells | - | Proliferation assay | - | Antiproliferative activity against human LOXIMVI cells by SRB assay, GI50=1.08 μM | 21621883 |
LOXIMVI cells | - | Cytotoxicity assay | - | Cytotoxicity against human LOXIMVI cells, LC50=6.04 μM | 21621883 |
M14 cells | - | Proliferation assay | - | Antiproliferative activity against human M14 cells by SRB assay, GI50=0.849 μM | 21621883 |
MALME-3M cells | - | Proliferation assay | - | Antiproliferative activity against human MALME-3M cells by SRB assay, GI50=0.461 μM | 21621883 |
MCF7 cells | - | Proliferation assay | - | Antiproliferative activity against human MCF7 cells by SRB assay, GI50=6.91 μM | 21621883 |
MDA-MB-231 cells | - | Proliferation assay | - | Antiproliferative activity against human MDA-MB-231 cells by SRB assay, GI50=31.7 μM | 21621883 |
MDA-MB-435 cells | - | Proliferation assay | - | Antiproliferative activity against human MDA-MB-435 cells by SRB assay, GI50=0.537 μM | 21621883 |
MDA-MB-435 cells | - | Cytotoxicity assay | - | Cytotoxicity against human MDA-MB-435 cells, LC50=28.8 μM | 21621883 |
MDA-MB-468 cells | - | Proliferation assay | - | Antiproliferative activity against human MDA-MB-468 cells by SRB assay, GI50=5.88 μM | 21621883 |
MOLT4 cells | - | Proliferation assay | - | Antiproliferative activity against human MOLT4 cells by SRB assay, GI50=0.311 μM | 21621883 |
NCI/ADR-RES cells | - | Proliferation assay | - | Antiproliferative activity against human NCI/ADR-RES cells by SRB assay, GI50=0.18 μM | 21621883 |
NCI-H226 cells | - | Proliferation assay | - | Antiproliferative activity against human NCI-H226 cells by SRB assay, GI50=1.41 μM | 21621883 |
NCI-H226 cells | - | Cytotoxicity assay | - | Cytotoxicity against human NCI-H226 cells, LC50=20 μM | 21621883 |
NCI-H23 cells | - | Proliferation assay | - | Antiproliferative activity against human NCI-H23 cells by SRB assay, GI50=1.5 μM | 21621883 |
NCI-H322M cells | - | Proliferation assay | - | Antiproliferative activity against human NCI-H322M cells by SRB assay, GI50=2.26 μM | 21621883 |
NCI-H460 cells | - | Proliferation assay | - | Antiproliferative activity against human NCI-H460 cells by SRB assay, GI50=0.7 μM | 21621883 |
OVCAR3 cells | - | Proliferation assay | - | Antiproliferative activity against human OVCAR3 cells by SRB assay, GI50=1.11 μM | 21621883 |
OVCAR4 cells | - | Proliferation assay | - | Antiproliferative activity against human OVCAR4 cells by SRB assay, GI50=3.21 μM | 21621883 |
OVCAR5 cells | - | Proliferation assay | - | Antiproliferative activity against human OVCAR5 cells by SRB assay, GI50=0.26 μM | 21621883 |
OVCAR5 cells | - | Cytotoxicity assay | - | Cytotoxicity against human OVCAR5 cells, LC50=38.9 μM | 21621883 |
OVCAR8 cells | - | Proliferation assay | - | Antiproliferative activity against human OVCAR8 cells by SRB assay, GI50=0.45 μM | 21621883 |
PC3 cells | - | Proliferation assay | - | Antiproliferative activity against human PC3 cells by SRB assay, GI50=20 μM | 21621883 |
RPMI8226 cells | - | Proliferation assay | - | Antiproliferative activity against human RPMI8226 cells by SRB assay, GI50=0.523 μM | 21621883 |
RXF393 cells | - | Proliferation assay | - | Antiproliferative activity against human RXF393 cells by SRB assay, GI50=0.01 μM | 21621883 |
RXF393 cells | - | Cytotoxicity assay | - | Cytotoxicity against human RXF393 cells, LC50=15.3 μM | 21621883 |
SF268 cells | - | Proliferation assay | - | Antiproliferative activity against human SF268 cells by SRB assay, GI50=1.53 μM | 21621883 |
SF295 cells | - | Proliferation assay | - | Antiproliferative activity against human SF295 cells by SRB assay, GI50=0.743 μM | 21621883 |
SF295 cells | - | Cytotoxicity assay | - | Cytotoxicity against human SF295 cells, LC50=6.91 μM | 21621883 |
SF539 cells | - | Proliferation assay | - | Antiproliferative activity against human SF539 cells by SRB assay, GI50=0.965 μM | 21621883 |
SK-MEL-28 cells | - | Proliferation assay | - | Antiproliferative activity against human SK-MEL-28 cells by SRB assay, GI50=0.993 μM | 21621883 |
SK-MEL-28 cells | - | Cytotoxicity assay | - | Cytotoxicity against human SK-MEL-28 cells, LC50=31.9 μM | 21621883 |
SK-MEL-5 cells | - | Proliferation assay | - | Antiproliferative activity against human SK-MEL-5 cells by SRB assay, GI50=0.271 μM | 21621883 |
SK-MEL-5 cells | - | Cytotoxicity assay | - | Cytotoxicity against human SK-MEL-5 cells, LC50=4.02 μM | 21621883 |
SKOV3 cells | - | Proliferation assay | - | Antiproliferative activity against human SKOV3 cells by SRB assay, GI50=0.524 μM | 21621883 |
SKOV3 cells | - | Cytotoxicity assay | - | Cytotoxicity against human SKOV3 cells, LC50=28.5 μM | 21621883 |
SN12C cells | - | Proliferation assay | - | Antiproliferative activity against human SN12C cells by SRB assay, GI50=3.92 μM | 21621883 |
SNB19 cells | - | Proliferation assay | - | Antiproliferative activity against human SNB19 cells by SRB assay, GI50=1.53 μM | 21621883 |
SNB19 cells | - | Cytotoxicity assay | - | Cytotoxicity against human SNB19 cells, LC50=31.7 μM | 21621883 |
SNB75 cells | - | Proliferation assay | - | Antiproliferative activity against human SNB75 cells by SRB assay, GI50=0.318 μM | 21621883 |
SR cells | - | Proliferation assay | - | Antiproliferative activity against human SR cells by SRB assay, GI50=2.99 μM | 21621883 |
SW620 cells | - | Proliferation assay | - | Antiproliferative activity against human SW620 cells by SRB assay, GI50=0.478 μM | 21621883 |
T47D cells | - | Proliferation assay | - | Antiproliferative activity against human T47D cells by SRB assay, GI50=28.8 μM | 21621883 |
TK10 cells | - | Proliferation assay | - | Antiproliferative activity against human TK10 cells by SRB assay, GI50=0.444 μM | 21621883 |
U251 cells | - | Proliferation assay | - | Antiproliferative activity against human U251 cells by SRB assay, GI50=0.773 μM | 21621883 |
U251 cells | - | Cytotoxicity assay | - | Cytotoxicity against human U251 cells, LC50=5.82 μM | 21621883 |
UACC257 cells | - | Proliferation assay | - | Antiproliferative activity against human UACC257 cells by SRB assay, GI50=0.393 μM | 21621883 |
UACC257 cells | - | Cytotoxicity assay | - | Cytotoxicity against human UACC257 cells, LC50=44.8 μM | 21621883 |
UACC62 cells | - | Proliferation assay | - | Antiproliferative activity against human UACC62 cells by SRB assay, GI50=0.379 μM | 21621883 |
UACC62 cells | - | Cytotoxicity assay | - | Cytotoxicity against human UACC62 cells, LC50=6.39 μM | 21621883 |
UO31 cells | - | Proliferation assay | - | Antiproliferative activity against human UO31 cells by SRB assay, GI50=0.452 μM | 21621883 |
靶点 | Description | IC50 |
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HDAC | IC50:32nM |
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