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CAS No.: 2227366-51-8

Dalbavancin HCl/盐酸达巴万星 Catalog No. CSN24272

Synonyms: MDL-63397 hydrochloride;BI-397 hydrochloride;盐酸达巴万星

Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively .

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生物活性

描述Dalbavancin (hydrochloride(1:x)), a lipoglycopeptide antibiotic agent that is active against gram-positive pathogens, has a long plasma half-life, allowing for once-weekly dosing. Once-weekly intravenous dalbavancin was not inferior to twice-daily intravenous vancomycin followed by oral linezolid for the treatment of acute bacterial skin and skin-structure infection^[3]. Dalbavancin, approved for acute bacterial skin and skin structure infections, has potent activity against gram-positive pathogens. A 2-dose regimen of weekly dalbavancin is effective and well tolerated for the treatment of osteomyelitis in adults^[4]. Dalbavancin was used to treat prosthetic joint infection (29.0%), acute bacterial skin and skin-structure infection (21.7%), osteomyelitis (17.4%) and catheter-related bacteraemia (11.6%). These infections were mainly caused by Staphylococcus aureus (27 isolates), coagulase-negative staphylococci (24 isolates) and Enterococcus spp. (11 isolates) ^[5]. In a randomized, controlled, double-blind, multinational, phase III trial, dalbavancin was noninferior to linezolid, with clinical success rates of 88.9% and 91.2%. In a randomized, open-label, multicentre, phase II trial, clinical success rates were 94% with dalbavancin and 76% with comparator antibacterials. Dalbavancin was generally well tolerated by adult patients with cSSSIs(complicated skin and skin structure infections), with most adverse events being of mild or moderate severity^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.5396 mL
- 2.6981 mL
- 5.3962 mL
- 5 mM
- 0.1079 mL
- 0.5396 mL
- 1.0792 mL
- 10 mM
- 0.0540 mL
- 0.2698 mL
- 0.5396 mL

技术信息

CAS号

2227366-51-8

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C88H101Cl3N10O28

运输

蓝冰

分子量

1853.15

别名

MDL-63397 hydrochloride;BI-397 hydrochloride;盐酸达巴万星

溶解度

DMSO	24.0 mg/mL (13.0 mM)
Water	50.0 mg/mL (27.0 mM) warming

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Dalbavancin HCl/盐酸达巴万星 Catalog No. CSN24272

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