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CAS No.: 334-48-5

癸酸 Catalog No. CSN25397

Synonyms: 癸酸;Decanoic Acid (C10

Decanoic acid belongs to the class of organic compounds known as medium-chain fatty acids.

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生物活性

描述Decanoic acid belongs to the class of organic compounds known as medium-chain fatty acids. Decanoic acid, but not the ketones β-hydroxybutryate or acetone, shows antiseizure activity in two acute ex vivo rat hippocampal slice models of epileptiform activity. It has a strong inhibitory effect on excitatory, but not inhibitory, neurotransmission in hippocampal slices. The direct inhibition of excitatory neurotransmission by decanoic acid in the brain contributes to the anti-convulsant effect of the medium chain triglyceride ketogenic diet^[2]. Decanoic acid, a component of medium-chain triclycerides, contributes to seizure control through direct α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inhibition, whereas drugs targeting lactate dehydrogenase reduce seizures through inhibition of a metabolic pathway^[3]. The presence of decanoic acid, even at a low concentration (0.2 g/L), inhibited the transformation of 10-hydroxydecanoic acid to sebacic acid. Moreover, about 24-32% reduction in the decanoic acid oxidation was observed in the presence of 0.5-1.5 g/L 10-hydroxydecanoic acid^[4]. Combination treatment using perampanel and dietary decanoic acid to provide enhanced seizure control^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.8050 mL
- 29.0251 mL
- 58.0502 mL
- 5 mM
- 1.1610 mL
- 5.8050 mL
- 11.6100 mL
- 10 mM
- 0.5805 mL
- 2.9025 mL
- 5.8050 mL

技术信息

CAS号

334-48-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H20O2

运输

蓝冰

分子量

172.26

别名

癸酸;Decanoic Acid (C10

溶解度

DMSO	32.0 mg/mL (185.8 mM)
Water	33.0 mg/mL (191.6 mM)
Ethanol	34.0 mg/mL (197.4 mM)

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