|7-[4-[4-(2,3-二氯苯基)-1-哌嗪基]丁氧基]-2(1H)-喹啉酮|CsnPharm

CAS No.: 129722-25-4

Dehydroaripiprazole Catalog No. CSN27302

Synonyms: OPC-14857;DM-14857

Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole^[5]. The polymorphic CYP2D6 enzyme metabolises the antipsychotic drugs risperidone and aripiprazole to their active metabolites, 9OH-risperidone and dehydroaripiprazole^[6]. CYP2D6 genotypes play an important role in controlling steady-state plasma concentrations of aripiprazole and the sum of aripiprazole and dehydroaripiprazole in Asian subjects, whereas CYP3A5 and ABCB1 genotypes seemed unlikely to have an impact^[7]. Aripiprazole and dehydroapripiprazole showed relatively strong inhibitory effects on human MDR1 with IC(50) values of 1.2 and 1.3 µm in human MDR1-transfected Mardin-Darby canine kidney (MDCKII-MDR1) cells, respectively. Aripiprazole and dehydroaripiprazole also had inhibition potencies against human BCRP with IC(50) values of 3.5 and 0.52 µm, respectively^[8].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2403 mL
- 11.2015 mL
- 22.4030 mL
- 5 mM
- 0.4481 mL
- 2.2403 mL
- 4.4806 mL
- 10 mM
- 0.2240 mL
- 1.1201 mL
- 2.2403 mL

技术信息

CAS号	129722-25-4	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C23H25Cl2N3O2	运输	蓝冰
分子量	446.37	别名	OPC-14857;DM-14857

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Dehydroaripiprazole Catalog No. CSN27302

靶点选择性

请登录您的专属账户

确认信息