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CAS No.: 111664-82-5

Dehydroevodiamine HCl/盐酸去氢吴茱萸碱 Catalog No. CSN14092

Synonyms: Dehydroevodiamine (hydrochloride);Dehydroevodiamine Chloride;盐酸去氢吴茱萸碱

Dehydroevodiamine HCl is an alkaloid isolated from E. rutaecarpa and possesses anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.

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技术信息

生物活性

描述Dehydroevodiamine (DHE) Hydrochloride (HCl) is an alkaloid isolated from E. rutaecarpa and possesses anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities. DHE administration had an excellent therapeutic impact on the AIA (adjuvant-induced arthritis) rat model, substantially relieving joint swelling, inhibiting synovial pannus hyperplasia, and decreasing joint scores^[2]. DHE suppressed the viability of HCT116, CT26, SW480, and LoVo cells. DHE treatment led to G2/M arrest via a reduction of cyclin B1/CDK1 and caspase-dependent apoptosis. It also induced autophagy by regulating LC3-II and beclin-1 expression. Additionally, migration and invasion of CRC cells were decreased by DHE through regulation of the expression of EMT markers. Oral administration of DHE could inhibit the lung metastasis of CT26 cells in an in vivo model^[3]. A single (20 mg/kg p.o.) and repeated (10 mg/kg p.o.) administrations of DHED (dehydroevodiamine.HCl) could significantly reverse the latency time shortened by scopolamine (1 mg/kg i.p.) to control level. The cognitive deficits caused by EC lesion and middle cerebral artery occlusion were improved significantly by repeated administrations of DHED (6.25 mg/kg i.p.) after EC lesion or ischemic insult once a day for 7 days in the passive avoidance test^[4].
参考文献

[1] Haji A, Momose Y, et al. Increased feline cerebral blood flow induced by dehydroevodiamine hydrochloride from Evodia rutaecarpa. J Nat Prod. 1994 Mar;57(3):387-9.
[2] Dai Y, Sheng J, He S, Wu Q, Wang Y, Su L. Dehydroevodiamine suppresses inflammatory responses in adjuvant-induced arthritis rats and human fibroblast-like synoviocytes. Bioengineered. 2022 Jan;13(1):268-279
[3] Jeon HD, Han YH, Mun JG, Yoon DH, Lee YG, Kee JY, Hong SH. Dehydroevodiamine inhibits lung metastasis by suppressing survival and metastatic abilities of colorectal cancer cells. Phytomedicine. 2022 Feb;96:153809
[4] Park CH, Lee YJ, Lee SH, Choi SH, Kim HS, Jeong SJ, Kim SS, Suh YH. Dehydroevodiamine.HCl prevents impairment of learning and memory and neuronal loss in rat models of cognitive disturbance. J Neurochem. 2000 Jan;74(1):244-53

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9603 mL
- 14.8015 mL
- 29.6031 mL
- 5 mM
- 0.5921 mL
- 2.9603 mL
- 5.9206 mL
- 10 mM
- 0.2960 mL
- 1.4802 mL
- 2.9603 mL

技术信息

CAS号

111664-82-5

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H16ClN3O

运输

蓝冰

分子量

337.80

别名

Dehydroevodiamine (hydrochloride);Dehydroevodiamine Chloride;盐酸去氢吴茱萸碱;去氢吴茱萸碱盐酸盐

溶解度

DMSO	18.0 mg/mL (53.3 mM) warming
Water	insoluble

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Dehydroevodiamine HCl/盐酸去氢吴茱萸碱 Catalog No. CSN14092

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