|4-(3-(二氟甲基)-5-(3-氟-4-甲氧基苯基)-1H-吡唑-1-基)苯磺酰胺|CsnPharm

CAS No.: 169590-41-4

Deracoxib/地拉考昔 Catalog No. CSN10773

Synonyms: SC 046;SC 46;SC 59046

Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID). Concentration of deracoxib required for 50% inhibition of cell viability (IC50) was reached in all 3 osteosarcoma cell lines and ranged from 70 to 150 microM, whereas the IC50 for piroxicam was only reached in the POS cell line at 500 microM. Neither deracoxib nor piroxicam induced sufficient toxicity in fibroblasts to reach an IC50. Deracoxib inhibited viability of cells at concentrations that did not affect fibroblast viability^[3]. Concomitant treatment of cells with piroxicam and deracoxib resulted in significant induction of apoptosis at lower concentrations and accumulation of cells in the G /G phase. Significant cytotoxic effects exhibited by the combination of piroxicam and deracoxib against canine mammary carcinoma cells in vitro suggest an attractive approach for the treatment of canine mammary carcinoma^[4]. Deracoxib exhibited an activity to prevent doxorubicin-mediated overproduction of nitric oxide in the cells. Deracoxib (50 and 100 μM) can be beneficial in protecting normal cells from the toxic effect of doxorubicin in conjunction with apoptosis by the modulation of nitric oxide production^[5]. Perioperative administration of deracoxib to dogs at 1-2 mg/kg/day for 3 days significantly improves analgesia in the postoperative surgical period after soft tissue surgery^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5165 mL
- 12.5827 mL
- 25.1654 mL
- 5 mM
- 0.5033 mL
- 2.5165 mL
- 5.0331 mL
- 10 mM
- 0.2517 mL
- 1.2583 mL
- 2.5165 mL

技术信息

CAS号

169590-41-4

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H14F3N3O3S

运输

蓝冰

分子量

397.37

别名

SC 046;SC 46;SC 59046;地拉考昔

溶解度

DMSO	80.0 mg/mL (201.3 mM)
Water	Insoluble
Ethanol	18.0 mg/mL (45.3 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Deracoxib/地拉考昔 Catalog No. CSN10773

靶点选择性

请登录您的专属账户

确认信息