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CAS No.: 15345-89-8

Desmethoxyyangonin/去甲氧基麻醉椒素 Catalog No. CSN12059

Synonyms: Demethoxyyangonin;5,6-Dehydrokavain;NSC 68686

Desmethoxyyangonin is a natural kavalactones isolated and purified from the Piper methysticum (kava) plant which is an ireversible inhibitor of MAO-B.

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描述Monoamine oxidases (MAOs) are mitochondrial bound enzymes, which catalyze the oxidative deamination of monoamine neurotransmitters. Inside the brain, MAOs are present in two isoforms: MAO-A and MAO-B. The activity of MAO-B is generally higher in patients affected by neurodegenerative diseases like Alzheimer's and Parkinson's^[2]. Kava-kava, a psychoactive beverage, induces relaxation, improves social interaction, promotes sleep and plays an important role in the sociocultural life in the islands of the South Pacific. Kava pyrones, the major constituents of kava kava, are generally considered to be responsible for the pharmacological activity in humans and animals. Desmethoxyyangonin, one of the six major kava pyrones found in the Piper methysticum (kava-kava) plant, is a reversible inhibitor of MAO-B. As the most potent kava pyrone, desmethoxyyangonin displays a competetive inhibition pattern with mean K_i 0.28 µM^[3]. A small dose of kava extract (20 mg/kg body weight i.p.) caused changes in rat behaviour and concentrations of dopamine in the nucleus accumbens. Higher doses (120 mg/kg i.p.) increased the levels of dopamine^[4]. Among the kava pyrones, only desmethoxyyangonin markedly induced the expression of CYP3A23^[5].
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实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.3813 mL
- 21.9064 mL
- 43.8129 mL
- 5 mM
- 0.8763 mL
- 4.3813 mL
- 8.7626 mL
- 10 mM
- 0.4381 mL
- 2.1906 mL
- 4.3813 mL

技术信息

CAS号	15345-89-8	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C14H12O3	运输	蓝冰
分子量	228.24	别名	Demethoxyyangonin;5,6-Dehydrokavain;NSC 68686;NSC 112161;trans-5,6-Dehydrokavain;去甲氧基醉椒素

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