|2-((4-((3-乙炔基苯基)氨基)-7-(2-甲氧基乙氧基)喹唑啉-6-基)氧基)乙醇盐酸盐|CsnPharm

CAS No.: 183320-51-6

Desmethyl Erlotinib HCl/去甲厄洛替尼盐酸盐 Catalog No. CSN15680

Synonyms: OSI-420;CP-373420 hydrochloride;DesMethyl Erlotinib HCl

OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00124657	Brain and Central Nervous Syst... more >>em Tumors Collapse <<	Phase 1 Phase 2	Completed	-	United States, California ... more >> University of California San Diego San Diego, California, United States, 92123-4282 United States, North Carolina Duke Children's Hospital and Health Center Durham, North Carolina, United States, 27710 United States, Tennessee St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 Collapse <<
NCT00754494	Adenomatous Polyp ... more >> Recurrent Colon Cancer Recurrent Rectal Cancer Stage I Colon Cancer Stage I Rectal Cancer Stage IIA Colon Cancer Stage IIA Rectal Cancer Stage IIB Colon Cancer Stage IIB Rectal Cancer Stage IIC Colon Cancer Stage IIC Rectal Cancer Stage IIIA Colon Cancer Stage IIIA Rectal Cancer Stage IIIB Colon Cancer Stage IIIB Rectal Cancer Stage IIIC Colon Cancer Stage IIIC Rectal Cancer Collapse <<	Phase 2	Completed	-	United States, California ... more >> VA Long Beach Healthcare System Long Beach, California, United States, 90822 Chao Family Comprehensive Cancer Center Orange, California, United States, 92868 United States, Illinois University of Illinois at Chicago Chicago, Illinois, United States, 60612 Collapse <<
NCT00124657	-	-	Completed	-	-

更多
参考文献

[1] Meany HJ, Fox E, et al. The plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite (OSI-420) after intravenous administration of erlotinib in non-human primates. Cancer Chemother Pharmacol. 2008 Aug;62(3):387-92. Epub 2007 Oct 12.
[2] Li T, Ling YH, et al. Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells. Clin Cancer Res. 2007 Jun 1;13(11):3413-22.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4046 mL
- 12.0230 mL
- 24.0460 mL
- 5 mM
- 0.4809 mL
- 2.4046 mL
- 4.8092 mL
- 10 mM
- 0.2405 mL
- 1.2023 mL
- 2.4046 mL

技术信息

CAS号	183320-51-6	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C21H22ClN3O4	运输	蓝冰
分子量	415.87	别名	OSI-420;CP-373420 hydrochloride;DesMethyl Erlotinib HCl;CP-473420

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00124657	Brain and Central Nervous Syst... more >>em Tumors Collapse <<	Phase 1 Phase 2	Completed	-	United States, California ... more >> University of California San Diego San Diego, California, United States, 92123-4282 United States, North Carolina Duke Children's Hospital and Health Center Durham, North Carolina, United States, 27710 United States, Tennessee St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 Collapse <<
NCT00754494	Adenomatous Polyp ... more >> Recurrent Colon Cancer Recurrent Rectal Cancer Stage I Colon Cancer Stage I Rectal Cancer Stage IIA Colon Cancer Stage IIA Rectal Cancer Stage IIB Colon Cancer Stage IIB Rectal Cancer Stage IIC Colon Cancer Stage IIC Rectal Cancer Stage IIIA Colon Cancer Stage IIIA Rectal Cancer Stage IIIB Colon Cancer Stage IIIB Rectal Cancer Stage IIIC Colon Cancer Stage IIIC Rectal Cancer Collapse <<	Phase 2	Completed	-	United States, California ... more >> VA Long Beach Healthcare System Long Beach, California, United States, 90822 Chao Family Comprehensive Cancer Center Orange, California, United States, 92868 United States, Illinois University of Illinois at Chicago Chicago, Illinois, United States, 60612 Collapse <<
NCT00124657	-	-	Completed	-	-
NCT00754494	-	-	Completed	-	-
NCT00925769	Pancreatic Cancer	Phase 1	Completed	-	Austria ... more >> Vienna, Austria, 1100 Wien, Austria, 1130 Collapse <<
NCT00482625	-	-	Terminated(The protocol has be... more >>en completed prematurely (e.g., due to poor accrual, insufficient drug supply, IND closure).) Collapse <<	-	-
NCT00482625	Intraductal Papillary Mucinous... more >> Neoplasm of the Pancreas Recurrent Pancreatic Cancer Stage IA Pancreatic Cancer Stage IB Pancreatic Cancer Stage IIA Pancreatic Cancer Stage IIB Pancreatic Cancer Stage III Pancreatic Cancer Collapse <<	Phase 2	Terminated(The protocol has be... more >>en completed prematurely (e.g., due to poor accrual, insufficient drug supply, IND closure).) Collapse <<	-	United States, California ... more >> University of California Medical Center At Irvine-Orange Campus Orange, California, United States, 92868 Collapse <<
NCT00925769	-	-	Completed	-	-
NCT02904850	-	-	Unknown	December 2016	France ... more >> Service de Pneumologie Nouvel Hôpital Civil Recruiting Strasbourg, Alsace, France, 67091 Sub-Investigator: Bertrand MENNECIER Sub-Investigator: Alain DUCOLONE Sub-Investigator: Nathalie PRIM Sub-Investigator: Cesar MATAU Sub-Investigator: Ashok PUROHIT Collapse <<

Desmethyl Erlotinib HCl/去甲厄洛替尼盐酸盐 Catalog No. CSN15680

靶点选择性

请登录您的专属账户

确认信息