|2-(2-((2,6-二氯苯基)氨基)苯基)乙酸钾|CsnPharm

CAS No.: 15307-81-0

Diclofenac potassium/双氯芬酸钾 Catalog No. CSN11951

Synonyms: CGP-45840B;双氯芬酸钾

CGP 45840B is a non-selective reversible and competitive inhibitor of COX, used as an anti-inflammatory drug and an analgesic agent.

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技术信息

生物活性

描述Diclofenac potassium is a nonsteroidal anti-inflammatory drug, which is used to reduce inflammation and relieve pain in some cases. Most strains of Gram-positive and Gram-negative bacteria were inhibited by 50-100 mg/l of the anti-inflammatory agent, diclofenac sodium (Dc). In vivo test using 30 or 50 mg Dc per 20 g mouse significantly (P <0.001) protected the animals when challenged with 50 MLD of a virulent Salmonella typhimurium. The anti-bacterial action of Dc was found to be due to inhibition of DNA synthesis which was demonstrated using 2 micro Ci (3H) deoxythymidine uptake^[3]. Premedication by a single, oral dose of 50 mg DFK (diclofenac potassium) could be effective in reducing postendodontic pain at 48 hours after 1-visit endodontic treatment in mandibular molars with symptomatic irreversible pulpitis^[4]. Diclofenac potassium is effective in relieving menstrual pain and restoring physical performance to levels achieved when the women were in the late-follicular (no menstruation, no pain) phase of the menstrual cycle^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9919 mL
- 14.9594 mL
- 29.9187 mL
- 5 mM
- 0.5984 mL
- 2.9919 mL
- 5.9837 mL
- 10 mM
- 0.2992 mL
- 1.4959 mL
- 2.9919 mL

技术信息

CAS号

15307-81-0

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H10Cl2KNO2

运输

蓝冰

分子量

334.24

别名

CGP-45840B;双氯芬酸钾

溶解度

DMSO	165.0 mg/mL (493.7 mM)
Water	45.0 mg/mL (134.6 mM) warming

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