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CAS No.: 484-29-7

Dictamnine/白鲜碱 Catalog No. CSN10796

Synonyms: Dictamnine;Dectamine;白鲜碱

Dictamnine, a natural product isolated and purified from the root barks of Dictamnus dasycarpus Turcz., has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells, and has antimicrobial activity against bacteria and fungi.

规格	价格	促销价格	库存	数量

400-920-2911

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技术信息

生物活性

描述Dictamnine, a natural plant product, has been reported to have antimicrobial activity against bacteria and fungi. Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml^[3]. Dictamnine exhibited no obvious antibacterial activity against UPEC, but significantly impeded the ability of UPEC (Uropathogenic Escherichia coli) to adhere to and invade uroepithelial cells^[4]. Among all cancer cell lines tested, Dic inhibited the proliferation of c-Met-dependent EBC-1 cells with the greatest potency (IC50 = 2.811 μM). Notably, Dic was shown to synergistically improve the chemo-sensitivity of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-resistant lung cancer cells to gefitinib and osimertinib^[5]. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which mitochondria and caspase were not involved and DHA (dihydroartemisinin) enhanced Dic induced A549 cell apoptosis via a caspase-dependent pathway^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.0199 mL
- 25.0997 mL
- 50.1994 mL
- 5 mM
- 1.0040 mL
- 5.0199 mL
- 10.0399 mL
- 10 mM
- 0.5020 mL
- 2.5100 mL
- 5.0199 mL

技术信息

CAS号

484-29-7

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H9NO2

运输

蓝冰

分子量

199.21

别名

Dictamnine;Dectamine;白鲜碱

溶解度

DMSO	33.0 mg/mL (165.7 mM)

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