|N,3,4-三羟基苯甲酰胺|CsnPharm

CAS No.: 69839-83-4

Didox/N,3,4-三羟基苯甲酰胺 Catalog No. CSN18398

Synonyms: NSC-324360;N,3,4-Trihydroxybenzamide

Didox can prevent LPS-induced NF-KB activation and translocation of NF-kappa beta p65 subunits.

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技术信息

生物活性

描述Didox is a synthetic antioxidant and a potent ribonucleotide reductase (RNR) inhibitor. Didox treatment of mouse bone marrow-derived mast cells (BMMC) reduced IgE-stimulated degranulation and cytokine production, including IL-6, IL-13, TNF and MIP-1a (CCL3). Furthermore, Didox increased expression of the antioxidant genes superoxide dismutase and catalase, and suppressed DCFH-DA fluorescence, indicating reduced reactive oxygen species production^[3]. Didox was active against all human and murine AML (Acute Myeloid Leukemia) lines tested with IC50 values in the low micromolar range (mean IC50 37 µM [range 25.89-52.70 µM]). Didox exposure resulted in DNA damage and p53 induction culminating in apoptosis. Didox was well tolerated and effective against preclinical models of AML^[4]. Didox induced caspase-dependent multiple myeloma (MM) cell apoptosis^[5]. Nuclear translocation of NF-κβ (p65) in response to LPS is inhibited by didox^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01401075	Gastric Cancer	Phase 4	Completed	-	Korea, Republic of ... more >> ASAN Medical Center Seoul, Korea, Republic of, 138-736 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.9124 mL
- 29.5622 mL
- 59.1244 mL
- 5 mM
- 1.1825 mL
- 5.9124 mL
- 11.8249 mL
- 10 mM
- 0.5912 mL
- 2.9562 mL
- 5.9124 mL

技术信息

CAS号

69839-83-4

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H7NO4

运输

蓝冰

分子量

169.13

别名

NSC-324360;N,3,4-Trihydroxybenzamide

溶解度

DMSO	95.0 mg/mL (561.7 mM) warming

动物实验配方

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Didox/N,3,4-三羟基苯甲酰胺 Catalog No. CSN18398

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