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CAS No.: 3658-80-8

Dimethyl trisulfide/二甲基三硫 Catalog No. CSN29525

Synonyms: Methyl trisulfide;DMTS;2

Dimethyl trisulfide is an organic chemical compound and the simplest organic trisulfide found in garlic, onion, broccoli, and similar plants. Dimethyl trisulfide is a cyanide antidote.

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生物活性

描述Dimethyl trisulfide is an organic chemical compound and the simplest organic trisulfide found in garlic, onion, broccoli, and similar plants. A dose of 100 mg/kg sodium thiosulfate given intramuscularly showed only slight therapeutic protection (APR = 1.1), whereas the antidotal protection from DMTS given intramuscularly at the same dose was substantial (APR = 3.3)^[1]. An analgesic effect of dimethyl trisulfide (DMTS), which was mediated by somatostatin released from nociceptor nerve endings acting on SST4 receptors. DMTS ameliorated neuropathic pain in Trpa1 and Sstr4 WT mice, but not in KO ones. DMTS had no effect on macrophage activity around the damaged nerve. Microglial density in the dorsal horn was reduced by DMTS independently from TRPA1^[2]. Intramuscular administration of DMTS improves survival and clinical outcomes in our large animal swine model of acute cyanide toxicity^[3]. DMTS is capable of oxidizing hemoglobin (Hb) to methemoglobin (MetHb) in vitro. The highest MetHb levels measured for the 50, 100, 200 and 250 mg/kg doses of DMTS were respectively 3.28, 6.12, 9.69, and 10.76% MetHb^[4].
参考文献

[1] Rockwood GA, Thompson DE, Petrikovics I. Dimethyl trisulfide: A novel cyanide countermeasure. Toxicol Ind Health. 2016 Dec;32(12):2009-2016
[2] Dombi Á, Sánta C, Bátai IZ, Kormos V, Kecskés A, Tékus V, Pohóczky K, Bölcskei K, Pintér E, Pozsgai G. Dimethyl Trisulfide Diminishes Traumatic Neuropathic Pain Acting on TRPA1 Receptors in Mice. Int J Mol Sci. 2021 Mar 25;22(7):3363
[3] Hendry-Hofer TB, Witeof AE, Lippner DS, Ng PC, Mahon SB, Brenner M, Rockwood GA, Bebarta VS. Intramuscular dimethyl trisulfide: efficacy in a large swine model of acute severe cyanide toxicity. Clin Toxicol (Phila). 2019 Apr;57(4):265-270
[4] Kiss M, Petrikovics I, Thompson DE. Methemoglobin Forming Effect of Dimethyl Trisulfide in Mice. Hemoglobin. 2018 Sep-Nov;42(5-6):315-319

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.9199 mL
- 39.5996 mL
- 79.1991 mL
- 5 mM
- 1.5840 mL
- 7.9199 mL
- 15.8398 mL
- 10 mM
- 0.7920 mL
- 3.9600 mL
- 7.9199 mL

技术信息

CAS号	3658-80-8	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C2H6S3	运输	蓝冰
分子量	126.26	别名	Methyl trisulfide;DMTS;2;3;4-trithiapentane;二甲基三硫;二甲基三硫化物

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