|丙二酸二甲酯|CsnPharm

CAS No.: 108-59-8

Synonyms: 丙二酸二甲酯

Dimethylmalonate is a competitive SDH (succinate dehydrogenase) inhibitor.

规格	价格	促销价格	库存	数量

400-920-2911

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400-920-2911

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生物活性

描述Dimethylmalonate is a competitive SDH (succinate dehydrogenase) inhibitor. It led to an increase in succinate in the cytosol, presumably by impairing the oxidation of succinate to fumarate, and also boosted LPS-induced succinate accumulation. Limiting succinate oxidation by dimethylmalonate induced an anti-inflammatory response at 10mM in BMDMs. Dimethylmalonate, at dose of 160 mg/kg, i.p., also showed anti-inflammatory effect on LPS-induced sepsis mice model. It decreased serum levels of IL-1β and boosted IL-10, but had no significant effect on TNF-α, as well as reduced IL-1β and PHD3 expression in the spleen^[1].
作用机制Dimethylmalonate is a competitive SDH inhibitor.
动物研究
剂量
mice: 160mg/kg, i.p.^[1]
参考文献

动物研究
剂量	mice: 160mg/kg, i.p.^[1]

实验方案

技术信息

CAS号	108-59-8	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C5H8O4	运输	蓝冰
分子量	132.11	别名	丙二酸二甲酯

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