|1-甲基-2-硝基-3-((四氢呋喃-3-基)甲基)胍|CsnPharm

CAS No.: 165252-70-0

Dinotefuran/呋虫胺 Catalog No. CSN16721

Synonyms: MTI-446;1-Methyl-2-nitro-3-((tetrahydrofuran-3-yl)methyl)guanidine;Nidinotefuran

Dinotefuran is the third generation of neonicotinoid group,which works through inhibiting nAchRs.

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技术信息

生物活性

描述Dinotefuran is a furanicotinyl insecticide belonging to the third generation of neonicotinoids. It acts specifically on the nervous system of fleas by inhibiting a nicotinic subclass of acetylcholine receptors. In vitro, the combination of dinotefuran and fipronil in a single formulation exhibited strong synergistic insecticidal activity against C. felis, and also proved effective on artificially infested cats^[3]. Moreover, exposure to DIN (Dinotefuran) in peripubertal male mice causes hyperactivity and a disturbance of dopaminergic signaling^[4].
参考文献

[1] Liu T, Wang X, et al. Biochemical and genetic toxicity of dinotefuran on earthworms (Eisenia fetida). Chemosphere. 2017 Jun;176:156-164.
[2] Chen Z, Dong F, et al. Response surface methodology for the enantioseparation of dinotefuran and its chiral metabolite in bee products and environmental samples by supercritical fluid chromatography/tandem mass spectrometry. J Chromatogr A. 2015 Sep 4;1410:181-9.
[3] Delcombel R, Karembe H, Nare B, Burton A, Liebenberg J, Fourie J, Varloud M. Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats. Parasit Vectors. 2017 Jul 19;10(1):341. doi: 10.1186/s13071-017-2272-8. PMID: 28724438; PMCID: PMC5517796.
[4] Yoneda N, Takada T, Hirano T, Yanai S, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Hoshi N. Peripubertal exposure to the neonicotinoid pesticide dinotefuran affects dopaminergic neurons and causes hyperactivity in male mice. J Vet Med Sci. 2018 Apr 18;80(4):634-637. doi: 10.1292/jvms.18-0014. Epub 2018 Feb 9. PMID: 29434093; PMCID: PMC5938192.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.9454 mL
- 24.7268 mL
- 49.4535 mL
- 5 mM
- 0.9891 mL
- 4.9454 mL
- 9.8907 mL
- 10 mM
- 0.4945 mL
- 2.4727 mL
- 4.9454 mL

技术信息

CAS号

165252-70-0

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H14N4O3

运输

蓝冰

分子量

202.21

别名

MTI-446;1-Methyl-2-nitro-3-((tetrahydrofuran-3-yl)methyl)guanidine;Nidinotefuran;呋虫胺

溶解度

Water

50.0 mg/mL (247.3 mM) warming

动物实验配方

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