|(2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3S,4S,5R,6R)-4-羟基-2-(羟甲基)-6-(((2'R,4S,5'R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5',6a,8a,9-四甲基-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-二十氢螺[萘并[2',1':4,5]茚并[2,1-b]呋喃-10,2'-吡喃]-4-基)氧基)四氢-2H-吡喃-3,5-二基)双(氧基))双(2-甲基四氢-2H-吡喃-3,4,5-三醇)|CsnPharm

CAS No.: 19057-60-4

Dioscin/薯蓣皂苷 Catalog No. CSN19485

Synonyms: Collettiside III;CCRIS 4123;Saponin

Dioscin, a natural product isolated and purified from the rhizome of Dioscorea Zingiberensis C.H.Wright, is a potent ITGA5 inhibitor, showing potent anti-cancer effect against a variety of tumor cell lines.

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描述Dioscin is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines. Dioscin (1, 2 and 4 μmol/L) could significantly inhibit the viability of LNCaP cells in a time- and concentration-dependent manner^[3]. Dioscin suppressed RANKL-mediated osteoclast differentiation and bone resorption in vitro in a dose-dependent manner. Dioscin abrogated AKT phosphorylation, which subsequently impaired RANKL-induced nuclear factor-kappaB (NF-κB) signaling pathway and inhibited NFATc1 transcriptional activity^[4]. Oral treatment dioscin delays crystalline silica-induced pulmonary fibrosis and exerts pulmonary protective effects in mice^[5]. Dioscin could promote autophagy in macrophages. Dioscin-triggered AMs autophagy limited mitochondrial reactive oxygen species (mtROS) mass stimulated by CS(crystalline silica), reduced mitochondria-dependent apoptosis pathway activation and facilitated cell survival. Dioscin treatment alleviated macrophage-derived inflammation and subsequent abnormal collagen repair^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1507 mL
- 5.7535 mL
- 11.5069 mL
- 5 mM
- 0.2301 mL
- 1.1507 mL
- 2.3014 mL
- 10 mM
- 0.1151 mL
- 0.5753 mL
- 1.1507 mL

技术信息

CAS号

19057-60-4

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C45H72O16

运输

蓝冰

分子量

869.04

别名

Collettiside III;CCRIS 4123;Saponin;薯蓣皂苷

溶解度

DMSO	150.0 mg/mL (172.6 mM)
Water	insoluble

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