|((2R,3S,4R,5R)-5-(2,4-二氧代-3,4-二氢嘧啶-1(2H)- 基)-3,4-二羟基四氢呋喃-2-基)甲基磷酸二钠盐|CsnPharm

CAS No.: 3387-36-8

尿苷酸二钠盐 Catalog No. CSN23370

Synonyms: Uridine 5'MP, disodium salt;Uridine 5'MP;disodium salt

Disodium uridine-5-monophosphate, a pyrimidine mononucleotide, can be converted to UTP. It has been used to study the effect of nucleotides on growth of specific intestinal bacteria.

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生物活性

描述Disodium uridine-5-monophosphate (UMP) is component used for RNA synthesis. Potassium (K+)-evoked DA release was significantly greater among UMP-treated (isodium uridine-5-monophosphate) rats. UMP treatment not only enhances membrane phosphatide production but also can modulate two membrane-dependent processes, neurotransmitter release and neurite outgrowth, in vivo^[1]. UMP adsorbs and charges the lipid membrane, resulting in the formation of unilamellar vesicles in dilute solutions. Adsorption of UMP reduces the bilayer thickness of DMPC. UMPDSS has a much weaker effect on interbilayer interactions. In the presence of counterions, such as Na+, UMP forms small aggregates in water, which bind to the bilayer without significantly perturbing it^[2].
参考文献

[1] Wang L, Pooler AM, Albrecht MA, Wurtman RJ. Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. J Mol Neurosci. 2005;27(1):137-145
[2] Sasidharan S, Pochinda S, Elgaard-Jørgensen PN, Rajamani S, Khandelia H, Raghunathan VA. Interaction of the mononucleotide UMP with a fluid phospholipid bilayer. Soft Matter. 2019;15(40):8129-8136

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7163 mL
- 13.5816 mL
- 27.1632 mL
- 5 mM
- 0.5433 mL
- 2.7163 mL
- 5.4326 mL
- 10 mM
- 0.2716 mL
- 1.3582 mL
- 2.7163 mL

技术信息

CAS号	3387-36-8	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C9H11N2Na2O9P	运输	蓝冰
分子量	368.15	别名	Uridine 5'MP, disodium salt;Uridine 5'MP;disodium salt;尿苷-5'-单磷酸二钠盐;5-单磷酸尿苷二钠

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