CAS No.: 139504-50-0
DM1 Catalog No. CSN13904
Synonyms: DM1;Maytansinoid DM1;DM1 Compound
Mertansine is a potent microtubule-targeted cytotoxic agent used in ADCs.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
动物研究 剂量 Rat: 0.48 mg/kg[3] (s.c.)
给药途径 s.c.
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01597414 Elderly Metastatic Breast Canc... more >>er Population Collapse << Phase 2 Active, not recruiting December 2018 Belgium ... more >> UZ Antwerpen Antwerpen, Belgium Cliniques Universitaires Saint-Luc Brussels, Belgium Institut Jules Bordet Brussels, Belgium Hopital De Jolimont Haine St Paul, Belgium AZ Groeninge Kortrijk Kortrijk, Belgium UZ Leuven Leuven, Belgium CHU Sart-Tilman Liège, Belgium Clinique et Maternité Sainte Elisabeth Namur, Belgium AZ Damiaan Oostende, Belgium AZ Nikolaas Sint-Niklaas, Belgium France Centre Georges-Francois-Leclerc Dijon, France Centre Oscar Lambret Lille, France Hopital Rene Huguenin - Institut Curie Saint-Cloud, France Centre Paul Strauss Strasbourg, France Italy Istituto Europeo Di Oncologia Milano, Italy Istituto Oncologico Veneto IRCCS - Ospedale Busonera Padova, Italy Netherlands Leiden University Medical Centre Leiden, Netherlands VieCuri - Medisch Centrum voor Noord-Limburg - Locatie Venlo Venlo, Netherlands Poland Maria Sklodowska-Curie Memorial Cancer Centre Warsaw, Poland Portugal Champalimaud Cancer Center Lisboa, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E. Lisboa, Portugal Sweden Sahlgrenska Universitetssjukhuet Goteborg, Sweden Ryhov County Hospital Jonkoping, Sweden Uppsala University Hospital - Akademiska Sjukhuset Uppsala, Sweden Vastmanland Centralsjukhuset Vasteras Vasteras, Sweden United Kingdom Velindre NHS Trust - Velindre Cancer Centre Cardiff, United Kingdom NHS Lothian - Western General Hospital Edinburgh, United Kingdom NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital Glasgow, United Kingdom Peterborough and Stamford Hospitals NHS Foundation Trust - Peterborough City Hospita Peterboroug, United Kingdom University Hospital Southampton NHS Foundation Trust - Southampton General Hospital Southampton, United Kingdom Collapse << NCT03523572 Breast Cancer ... more >> Urothelial Carcinoma Collapse << Phase 1 Recruiting September 2020 United States, California ... more >> UCLA - Medical Center Recruiting Santa Monica, California, United States, 90404-2125 Contact: Principal Investigator 310-829-5471 shurvitz@mednet.ucla.edu United States, New York Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029-6504 Contact: Principal Investigator 212-241-3131 charles.shapiro@mssm.edu United States, Tennessee Tennessee Oncology - Sara Cannon Research Institute Recruiting Nashville, Tennessee, United States, 37203-1619 Contact: Principal Investigator 615-329-7274 ehamilton@tnonc.com Italy Fondazione IRCCS Istituto Nazionale dei Tumori Recruiting Milano, Italy, 20133 Contact: Principal Investigator +39 223902402 andrea.necchi@istitutotumori.mi.it Collapse << NCT01976169 Advanced Breast Cancer Phase 1 Recruiting December 2020 United States, Texas ... more >> UT Southwestern Medical Center Recruiting Dallas, Texas, United States, 75390 Contact: Barbara Haley, MD 214-648-4180 barbara.haley@utsouthwestern.edu Contact: Gregg Wright 214-648-7097 James.Wright@UTSouthwestern.edu Sub-Investigator: Dawn Klemow, MD Sub-Investigator: Erik Knudsen, MD Sub-Investigator: Navid Sadeghi, MD Sub-Investigator: Lori Watumull, MD Principal Investigator: Barbara Haley, MD Collapse << - 更多
- 参考文献
- [1] Lopus M, Oroudjev E, et al. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther. 2010 Oct;9(10):2689-99.
- [2] Tijink BM, Buter J, et al. A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6064-72.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 139504-50-0 | 储存条件 |
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| 分子式 | C35H48ClN3O10S | 运输 | 蓝冰 | |||||
| 分子量 | 738.29 | 别名 | DM1;Maytansinoid DM1;DM1 Compound;DM1 [Maytansinoid];UNII-DDZ29HGH0E;maytansine;emtansine | |||||
| 溶解度 |
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动物实验配方 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT01597414 | Elderly Metastatic Breast Canc... more >>er Population Collapse << | Phase 2 | Active, not recruiting | December 2018 | Belgium ... more >> UZ Antwerpen Antwerpen, Belgium Cliniques Universitaires Saint-Luc Brussels, Belgium Institut Jules Bordet Brussels, Belgium Hopital De Jolimont Haine St Paul, Belgium AZ Groeninge Kortrijk Kortrijk, Belgium UZ Leuven Leuven, Belgium CHU Sart-Tilman Liège, Belgium Clinique et Maternité Sainte Elisabeth Namur, Belgium AZ Damiaan Oostende, Belgium AZ Nikolaas Sint-Niklaas, Belgium France Centre Georges-Francois-Leclerc Dijon, France Centre Oscar Lambret Lille, France Hopital Rene Huguenin - Institut Curie Saint-Cloud, France Centre Paul Strauss Strasbourg, France Italy Istituto Europeo Di Oncologia Milano, Italy Istituto Oncologico Veneto IRCCS - Ospedale Busonera Padova, Italy Netherlands Leiden University Medical Centre Leiden, Netherlands VieCuri - Medisch Centrum voor Noord-Limburg - Locatie Venlo Venlo, Netherlands Poland Maria Sklodowska-Curie Memorial Cancer Centre Warsaw, Poland Portugal Champalimaud Cancer Center Lisboa, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E. Lisboa, Portugal Sweden Sahlgrenska Universitetssjukhuet Goteborg, Sweden Ryhov County Hospital Jonkoping, Sweden Uppsala University Hospital - Akademiska Sjukhuset Uppsala, Sweden Vastmanland Centralsjukhuset Vasteras Vasteras, Sweden United Kingdom Velindre NHS Trust - Velindre Cancer Centre Cardiff, United Kingdom NHS Lothian - Western General Hospital Edinburgh, United Kingdom NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital Glasgow, United Kingdom Peterborough and Stamford Hospitals NHS Foundation Trust - Peterborough City Hospita Peterboroug, United Kingdom University Hospital Southampton NHS Foundation Trust - Southampton General Hospital Southampton, United Kingdom Collapse << |
| NCT03523572 | Breast Cancer ... more >> Urothelial Carcinoma Collapse << | Phase 1 | Recruiting | September 2020 | United States, California ... more >> UCLA - Medical Center Recruiting Santa Monica, California, United States, 90404-2125 Contact: Principal Investigator 310-829-5471 shurvitz@mednet.ucla.edu United States, New York Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029-6504 Contact: Principal Investigator 212-241-3131 charles.shapiro@mssm.edu United States, Tennessee Tennessee Oncology - Sara Cannon Research Institute Recruiting Nashville, Tennessee, United States, 37203-1619 Contact: Principal Investigator 615-329-7274 ehamilton@tnonc.com Italy Fondazione IRCCS Istituto Nazionale dei Tumori Recruiting Milano, Italy, 20133 Contact: Principal Investigator +39 223902402 andrea.necchi@istitutotumori.mi.it Collapse << |
| NCT01976169 | Advanced Breast Cancer | Phase 1 | Recruiting | December 2020 | United States, Texas ... more >> UT Southwestern Medical Center Recruiting Dallas, Texas, United States, 75390 Contact: Barbara Haley, MD 214-648-4180 barbara.haley@utsouthwestern.edu Contact: Gregg Wright 214-648-7097 James.Wright@UTSouthwestern.edu Sub-Investigator: Dawn Klemow, MD Sub-Investigator: Erik Knudsen, MD Sub-Investigator: Navid Sadeghi, MD Sub-Investigator: Lori Watumull, MD Principal Investigator: Barbara Haley, MD Collapse << |
| NCT02657343 | Breast Cancer | Phase 1 Phase 2 | Recruiting | February 2023 | United States, Massachusetts ... more >> Massacusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Aditya Bardia, MD 617-724-4000 Principal Investigator: Aditya Bardia, MD Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Sara Tolaney, MD MPH 617-632-3800 sara_tolaney@dfci.harvard.edu Principal Investigator: Sara Tolaney, MD MPH Collapse << |
| NCT03530696 | HER2-positive Breast Cancer ... more >> Breast Cancer Breast Cancer Stage Recurrent Breast Cancer Metastatic Breast Cancer HER2 Positive Breast Carcinoma Collapse << | Phase 2 | Not yet recruiting | August 1, 2022 | - |
| NCT03248492 | Breast Cancer | Phase 2 | Active, not recruiting | February 2020 | - |
| NCT02514681 | HER2-positive Locally Advanced... more >> or Metastatic Breast Cancer Collapse << | Phase 3 | Recruiting | July 2019 | Japan ... more >> Aichi Cancer Center Hospital Recruiting Chikusa-ku, Aichi, Japan, 4648681 Contact: Hiroji Iwata, MD, PhD +81-52-762-6111 Principal Investigator: Hiroji Iwata, MD, PhD Kumamoto University Hospital Recruiting Kumamoto City, Kumamoto, Japan, 8608556 Contact: Yutaka Yamamoto, MD, PhD +81-96-373-5521 Principal Investigator: Yutaka Yamamoto, MD, PhD Japan Breast Cancer Research Group Recruiting Chuo-ku, Nihonbashi, Koami-cho, Tokyo, Japan, 1030016 Contact +81-3-6264-8873 office@jbcrg.jp Collapse << |
| NCT01565200 | HER-2 Positive Breast Cancer | Phase 2 | Active, not recruiting | December 2019 | Belgium ... more >> Universitair Ziekenhuis Antwerpen (UZA) Antwerpen, Edegem, Belgium, 2650 Institut Jules Bordet Brussels, Belgium, 1000 Netherlands Vrije Universiteit Amsterdam (VUMC) Amsterdam, Netherlands, 1081HV University Medical Center Groningen (UMCG) Groningen, Netherlands, 9700RB Radboud University Medical Centre Nijmegen (UMCN) Nijmegen, Netherlands, 6525 GA Collapse << |
| NCT01120561 | - | - | - | - | United States, California ... more >> Investigational Site Highland, California, United States, 92346 Investigational Site Stockton, California, United States, 95204 United States, Colorado Investigational Site Denver, Colorado, United States, 80220 United States, Florida Investigational Site Plantation, Florida, United States, 33324 United States, Indiana Investigational Site Lafayette, Indiana, United States, 47905 United States, Iowa Investigational Site Cedar Rapids, Iowa, United States, 52403 United States, Maine Investigational Site Scarborough, Maine, United States, 04074 United States, Maryland Investigational Site Baltimore, Maryland, United States, 21231 United States, Michigan Investigational Site Detroit, Michigan, United States, 48201 United States, Missouri Investigational Site Clarkson Valley, Missouri, United States, 63011 United States, New Mexico Investigational Site Farmington, New Mexico, United States, 87401 United States, North Carolina Investigational Site Charlotte, North Carolina, United States, 28203 United States, South Carolina Investigational Site Charleston, South Carolina, United States, 29403 United States, Virginia Investigational Site Fairfax, Virginia, United States, 22031 United States, Washington Investigational Site Seattle, Washington, United States, 98109 Collapse << |
| NCT00928330 | Metastatic Breast Cancer | Phase 1 | Completed | - | United States, Indiana ... more >> Indianapolis, Indiana, United States, 46202 United States, Maryland Baltimore, Maryland, United States, 21231 United States, Massachusetts Boston, Massachusetts, United States, 02115 Collapse << |
| NCT01835236 | Metastatic Breast Cancer | Phase 2 | Active, not recruiting | November 30, 2019 | - |
| NCT01042379 | Breast Neoplasms ... more >> Breast Cancer Breast Tumors Collapse << | Phase 2 | Recruiting | - | - |
| NCT03523585 | Breast Cancer | Phase 3 | Recruiting | February 2022 | United States, California ... more >> Cancer Research Collaboration Recruiting Santa Ana, California, United States, 92705 Contact: Principal Investigator 562-981-6101 wademsmith@breastlink.com United States, District of Columbia Washington Cancer Institute Recruiting Washington, District of Columbia, United States, 20010 Contact: Principal Investigator 202-877-9386 christopher.gallagher@medstar.net United States, Georgia Piedmont Cancer Institute, PC Recruiting Atlanta, Georgia, United States, 30318 Contact: Principal Investigator 717-724-6780 rsinha@piedmontcancerinstitute.com United States, New York North Shore Hematology Oncology Associates, PC Recruiting East Setauket, New York, United States, 11733 Contact: Principal Investigator 631-675-5111 researchpi@nycancer.com United States, Ohio Dayton Physicians, LLC Recruiting Kettering, Ohio, United States, 45409 Contact: Principal Investigator 937-771-2422 cbane@precisioncancerresearch.com United States, Utah Northern Utah Associates Recruiting Ogden, Utah, United States, 84405 Contact: Principal Investigator 801-387-7166 nua2@outlook.com United States, Washington MultiCare Health System Institute for Research and Innovation Recruiting Tacoma, Washington, United States, 98405 Contact: Principal Investigator 253-403-3321 anu.belur@multicare.org Japan NHO Shikoku Cancer Center Recruiting Ehime, Japan, 791-0280 Contact: See Central Contact NHO Kyushu Cancer Center Recruiting Fukuoka, Japan, 811-1395 Contact: See Central Contact Hiroshima City Hiroshima Citizens Hospital Recruiting Hiroshima, Japan, 730-8518 Contact: See Central Contact NHO Hokkaido Cancer Center Recruiting Hokkaido, Japan, 003-0804 Contact: See Central Contact Hyōgo College of Medicine Hospital Recruiting Hyōgo, Japan, 663-8501 Contact: See Central Contact Kanagawa Cancer Center Recruiting Kanagawa, Japan, 241-8515 Contact: See Central Contact Tohoku University Hospital Recruiting Miyagi, Japan, 980-8574 Contact: See Central Contact Niigata Cancer Center Hospital Recruiting Niigata, Japan, 951-8566 Contact: See Central Contact Okayama University Hospital Recruiting Okayama, Japan, 700-8558 Contact: See Central Contact NHO Osaka National Hospital Recruiting Osaka, Japan, 540-0006 Contact: See Central Contact Osaka International Cancer Institute Recruiting Osaka, Japan, 541-8567 Contact: See Central Contact Saitama Cancer Center Recruiting Saitama, Japan, 362-0806 Contact: See Central Contact The Cancer Institute Hospital of JFCR Recruiting Tokyo, Japan, 135-8550 Contact: See Central Contact Tokyo Medical University Hospital Recruiting Tokyo, Japan, 160-0023 Contact: See Central Contact Collapse << |
| NCT03264547 | Breast Cancer | Phase 3 | Recruiting | October 31, 2023 | Japan ... more >> Kanagawa Cancer Center Not yet recruiting Yokohama, Kanagawa, Japan, 241-8515 Contact: Toshinari Yamashita, MD,PhD +81-45-520-2222 tyamashita@kcch.jp National Hospital Organization Osaka National Hospital Recruiting Ōsaka, Osaka, Japan, 540-0006 Contact: Norikazu Masuda, MD,PhD +81-6-6942-1331 nmasuda@alpha.ocn.ne.jp Collapse << |
| NCT03379428 | Breast Neoplasms ... more >> Malignant Neoplasm of Breast Collapse << | Phase 1 Phase 2 | Recruiting | December 2021 | United States, Texas ... more >> 10 sites incl TX, WA, VA, and NV Recruiting Dallas, Texas, United States, 75246 Contact: Site Research Coordinator Collapse << |
| NCT02568839 | Early-Stage Breast Carcinoma ... more >> HER-2 Positive Breast Cancer Collapse << | Phase 2 Phase 3 | Recruiting | December 2022 | Sweden ... more >> Dept. of Oncology, Örebro University Hospital Not yet recruiting Örebro, Närke, Sweden Principal Investigator: Johan Ahlgren, Assoc prof Dept. of Oncology, Sahlgrenska University Hospital Recruiting Göteborg, Sweden, 413 45 Contact: Kajsa Holgersson, RN kajsa.holgersson@vgregion.se Principal Investigator: Zakaria Einbeigi, MD, PhD Dept. of Oncology, Skåne University Hospital Recruiting Lund, Sweden Contact: Suzy Lindberg, RN suzylindberg@skane.se Principal Investigator: Eva Karlsson, MD, PhD Dept. of Oncology, Karolinska University Hospital Recruiting Stockholm, Sweden, 17176 Contact: Ingrid Lundin, RN ingrid.lundin@karolinska.se Contact: Gittan Nässén, RN birgitta.nassen@karolinska.se Principal Investigator: Theodoros Foukakis, Assoc prof Sub-Investigator: Ellinor Elinder, MD Dept. of Oncology, Sundsvall Hospital Recruiting Sundsvall, Sweden, 851 86 Contact: Christin Näslund, RN christine.naslund@lvn.se Principal Investigator: Lena Carlsson, MD Dept. of Oncology, University Hospital of Umeå Not yet recruiting Umeå, Sweden Contact: Lena Bylund, RN lena.bylund@vll.se Principal Investigator: Anne Andersson, MD Dept. of Oncology, Uppsala University Hospital Not yet recruiting Uppsala, Sweden Contact: Camilla Taavo, RN camilla.taavo@akademiska.se Principal Investigator: Henrik Lindman, Assoc prof Collapse << |
| NCT02390427 | Metastatic Breast Cancer ... more >> Recurrent Breast Cancer Collapse << | Phase 1 | Recruiting | October 2020 | United States, Massachusetts ... more >> Massacusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Dejan Juric, MD 617-724-6500 djuric@partners.org Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Ian Krop, MD, PhD 617-632-6973 IKROP@PARTNERS.ORG United States, Tennessee Sarah Cannon Research Institute Recruiting Nashville, Tennessee, United States, 37203 Contact: Erika Hamilton, MD ehamilton@tnonc.com Collapse << |
| NCT02465060 | Advanced Malignant Solid Neopl... more >>asm Bladder Carcinoma Breast Carcinoma Cervical Carcinoma Colon Carcinoma Colorectal Carcinoma Endometrial Carcinoma Esophageal Carcinoma Gastric Carcinoma Glioma Head and Neck Carcinoma Kidney Carcinoma Liver and Intrahepatic Bile Duct Carcinoma Lung Carcinoma Lymphoma Malignant Uterine Neoplasm Melanoma Ovarian Carcinoma Pancreatic Carcinoma Plasma Cell Myeloma Prostate Carcinoma Rectal Carcinoma Recurrent Bladder Carcinoma Recurrent Breast Carcinoma Recurrent Cervical Carcinoma Recurrent Colon Carcinoma Recurrent Colorectal Carcinoma Recurrent Esophageal Carcinoma Recurrent Gastric Carcinoma Recurrent Glioma Recurrent Head and Neck Carcinoma Recurrent Liver Carcinoma Recurrent Lung Carcinoma Recurrent Lymphoma Recurrent Malignant Solid Neoplasm Recurrent Melanoma Recurrent Ovarian Carcinoma Recurrent Pancreatic Carcinoma Recurrent Plasma Cell Myeloma Recurrent Prostate Carcinoma Recurrent Rectal Carcinoma Recurrent Skin Carcinoma Recurrent Thyroid Gland Carcinoma Recurrent Uterine Corpus Carcinoma Refractory Lymphoma Refractory Malignant Solid Neoplasm Refractory Plasma Cell Myeloma Skin Carcinoma Thyroid Gland Carcinoma Uterine Corpus Cancer Collapse << | Phase 2 | Recruiting | - | - |
| NCT02305641 | - | - | Recruiting | December 23, 2019 | Korea, Republic of ... more >> Inje University Busan Paik Hospital Recruiting Busan, Korea, Republic of, 47392 Inje university Haeundae Paik Hospital Terminated Busan, Korea, Republic of, 48108 Dong-A University Hospital Active, not recruiting Busan, Korea, Republic of, 49201 Pusan National University Hospital Recruiting Busan, Korea, Republic of, 49241 Kosin University Gospel Hospital Recruiting Busan, Korea, Republic of, 49267 Kyungpook National University Chilgok Hospital Recruiting Daegu, Korea, Republic of, 41404 Keimyung University Dongsan Medical Center Recruiting Daegu, Korea, Republic of, 41931 The Catholic University of Korea Daejeon ST. Mary's Hospital Recruiting Daejeon, Korea, Republic of, 34943 Chungnam National University Hospital Recruiting Daejeon, Korea, Republic of, 35015 Chonnam National University Hospital Recruiting Gwangju, Korea, Republic of, 61469 Uijeongbu St. Mary's Hospital Active, not recruiting Gyeonggi-do, Korea, Republic of, 11765 Hallym University Sacred Heart Hospital Recruiting Gyeonggi-do, Korea, Republic of, 14068 Soonchunhyang University Bucheon Hospital Recruiting Gyeonggi-do, Korea, Republic of, 14584 Bucheon St Mary's hospital Recruiting Gyeonggi-do, Korea, Republic of, 14647 St. Vincent's Hospital Recruiting Gyeonggi-do, Korea, Republic of, 16247 Ajou University Hospital Active, not recruiting Gyeonggi-do, Korea, Republic of, 443-380 Pusan National University Yangsan Hospital Recruiting Gyeongsangnam-do, Korea, Republic of, 50612 Gachon University Gil Medical Center Recruiting Incheon, Korea, Republic of, 21565 Inha University Hospital Recruiting Incheon, Korea, Republic of, 22332 Catholic Kwandong University International St. Mary'S Hospital. Recruiting Incheon, Korea, Republic of Chonbuk National Uni Hospital Recruiting Jeollabuk-do, Korea, Republic of, 561-712 Chonnam National University Hwasun Hospital Recruiting Jeollanam-do, Korea, Republic of, 58128 Presbyterian Medical Center Recruiting Jeonju-si, Korea, Republic of, 54987 NHIC Ilsan Hospital Recruiting Kyonggi-do, Korea, Republic of, 411-719 Korea Cancer Hospital of Korea Institute of Radiological and Medical Sciences Recruiting Seoul, Korea, Republic of, 01812 Korea University Anam Hospital Recruiting Seoul, Korea, Republic of, 02841 Seoul National University Hospital Recruiting Seoul, Korea, Republic of, 03080 Kangbuk Samsung Hospital Completed Seoul, Korea, Republic of, 03181 Severance Hospital, Yonsei University Health System; Pharmacy Recruiting Seoul, Korea, Republic of, 03722 Konkuk University Medical Center Recruiting Seoul, Korea, Republic of, 05030 Asan Medical Center Recruiting Seoul, Korea, Republic of, 05505 Gangnam Severance Hospital Active, not recruiting Seoul, Korea, Republic of, 06273 ChungAng University Hospital Recruiting Seoul, Korea, Republic of, 06973 Yeouido St. Mary's Hospital Recruiting Seoul, Korea, Republic of, 07345 Ewha Womans University Mokdong Hospital Recruiting Seoul, Korea, Republic of, 07985 SMG-SNU Boramae Medical Center Recruiting Seoul, Korea, Republic of, 156-707 Samsung Medical Center Recruiting Seoul, Korea, Republic of, 6351 Ulsan University Hosiptal Recruiting Ulsan, Korea, Republic of, 44033 Collapse << |
| NCT03190967 | Breast Cancer ... more >> Brain Metastasis Brain Cancer Collapse << | Phase 1 Phase 2 | Recruiting | June 30, 2023 | United States, Maryland ... more >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office 888-624-1937 Collapse << |
| NCT02213744 | Breast Cancer ... more >> HER2 Positive Breast Cancer Collapse << | Phase 2 Phase 3 | Terminated(Felt not to show be... more >>nefit over control per DMC and confirmed via futility analysis) Collapse << | June 2017 | - |
| NCT02564900 | Advanced Solid Tumors | Phase 1 | Active, not recruiting | September 2019 | United States, California ... more >> Sharp Memorial Hospital San Diego, California, United States, 92123 United States, Florida Mayo Clinic Jacksonville, Florida, United States, 32224 United States, Kentucky University of Louisville Louisville, Kentucky, United States, 40202 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Ohio UC Health Clinical Trials Office Cincinnati, Ohio, United States, 45229 United States, Texas University of Texas M. D. Anderson Cancer Center Houston, Texas, United States, 77030-3721 Japan Aichi Cancer Center Hospital Aichi, Japan National Cancer Center Hospital East Chiba, Japan Social Medical Corporation Hakuaikai Sagara Hospital Kagoshima, Japan Kindai University Hospital Osaka, Japan National Cancer Center Hospital Tokyo, Japan The Cancer Institute Hospital of Japanese Foundation For Cancer Research Tokyo, Japan Collapse << |
| NCT02229149 | Breast Neoplasms ... more >> Malignant Tumor of the Breast Collapse << | Phase 2 | Active, not recruiting | December 31, 2019 | United States, Texas ... more >> 19 Sites Multiple Locations, Texas, United States Collapse << |
| NCT00932373 | Metastatic Breast Cancer | Phase 1 | Completed | - | - |
| NCT02562378 | Breast Cancer | Phase 1 | Recruiting | October 2019 | France ... more >> MedSIR investigative site Not yet recruiting Paris, France, 75020 MedSIR investigative site Recruiting Paris, France, 92210 Spain MedSIR investigative site Recruiting Barcelone, Spain, 00835 MedSIR investigative site Recruiting Madrid, Spain, 08035 Collapse << |
| NCT03709082 | HER2-positive Breast Cancer ... more >> Breast Cancer Metastatic Collapse << | Phase 1 Phase 2 | Recruiting | October 15, 2025 | United States, Kansas ... more >> The University of Kansas Cancer Center, West Clinic Recruiting Kansas City, Kansas, United States, 66112 Contact: Clinical Trials Nurse Navigator 913-945-7552 ctnursenav@kumc.edu The University of Kansas Cancer Center, Westwood Campus Recruiting Kansas City, Kansas, United States, 66205 Contact: Clinical Trials Nurse Navigator 913-945-7552 ctnursenav@kumc.edu The University of Kansas Cancer Center, Overland Park Clinic Recruiting Overland Park, Kansas, United States, 66210 Contact: Clinical Trials Nurse Navigator 913-945-7552 ctnursenav@kumc.edu United States, Missouri The University of Kansas Cancer Center, North Clinic Recruiting Kansas City, Missouri, United States, 64154 Contact: Clinical Trials Nurse Navigator 913-945-7552 ctnursenav@kumc.edu The University of Kansas Cancer Center, Lee's Summit Clinic Recruiting Lee's Summit, Missouri, United States, 64064 Contact: Clinical Trials Nurse Navigator 913-945-7552 ctnursenav@kumc.edu Collapse << |
| NCT00932373 | - | - | Completed | - | - |
| NCT02326974 | HER-2 Positive Breast Cancer ... more >> Breast Cancer Stage II Breast Cancer Stage III Breast Cancer Collapse << | Phase 2 | Recruiting | April 2022 | United States, Massachusetts ... more >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Aditya Bardia, MD 617-643-2208 abardia1@partners.org Principal Investigator: Aditya Bardia, MD Beth Israel Deaconess Medical Center Withdrawn Boston, Massachusetts, United States, 02215 Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Ian Krop, MD, PhD 617-632-6973 IKROP@PARTNERS.ORG United States, Missouri Menorah Medical Center Recruiting Kansas City, Missouri, United States, 66209 Contact: Stephanie Graff, MD 913-541-7400 Stephanie.graff@hcahealthcare.com Principal Investigator: Stephanie Graff, MD United States, Tennessee Tennessee Oncology/Sarah Cannon Research Institute Recruiting Nashville, Tennessee, United States, 37203 Contact: Denise Yardley, MD 877-691-7274 dyardley@tnonc.com Principal Investigator: Denise Yardley, MD Vanderbilt-Ingram Cancer Center Recruiting Nashville, Tennessee, United States, 37232 Contact: Ingrid Mayer, MD ingrid.mayer@vanderbilt.edu Principal Investigator: Ingrid Mayer, MD Collapse << |
| NCT02038010 | HER2-positive Breast Cancer ... more >> Recurrent Breast Cancer Stage IIIA Breast Cancer Stage IIIB Breast Cancer Stage IIIC Breast Cancer Stage IV Breast Cancer Collapse << | Phase 1 | Active, not recruiting | March 2020 | United States, Illinois ... more >> Northwestern University Chicago, Illinois, United States, 60611 Collapse << |
| NCT02314481 | Non-small Cell Lung Cancer | Phase 2 | Recruiting | January 2023 | United Kingdom ... more >> Univeristy College London Hospital Recruiting London, United Kingdom Contact: Amy Smith Collapse << |
| NCT02318901 | Advanced Cancer ... more >> Breast Cancer Gastric Cancer Esophageal Cancer Colorectal Cancer Collapse << | Phase 1 Phase 2 | Terminated(PI no longer at sig... more >>ht. Results not collected) Collapse << | - | United States, Arizona ... more >> Western Regional Medical Center/Cancer Treatment Center of America Goodyear, Arizona, United States, 85338 Collapse << |
| NCT03587740 | Breast Cancer | Phase 2 | Recruiting | January 31, 2025 | United States, Maine ... more >> Eastern Maine Medical Center Recruiting Brewer, Maine, United States, 04412 Contact: Laurie Lewis 207-973-4249 llewis@northernlight.org Principal Investigator: Thomas Openshaw, MD United States, Massachusetts Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Rachel Freedman, MD MPH 617-632-4587 rafreedman@partners.org Principal Investigator: Rachel Freedman, MD MPH Massachusetts General Hospital Not yet recruiting Boston, Massachusetts, United States, 02215 Contact: Laura Spring, MD 617-724-4000 Lspring2@partners.org Principal Investigator: Laura Spring, MD Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center Recruiting Milford, Massachusetts, United States, 01757 Dana-Farber/Brigham and Women's Cancer Center in clinical affiliation with South Shore Hospital Recruiting South Weymouth, Massachusetts, United States, 02190 United States, New Hampshire Dana-Farber/New Hampshire Oncology-Hematology Recruiting Londonderry, New Hampshire, United States, 03053 United States, New York Memorial Sloan Kettering Cancer Center Not yet recruiting New York, New York, United States, 10065 United States, Tennessee Sarah Cannon Research Institute Not yet recruiting Nashville, Tennessee, United States, 37203 Collapse << |
| NCT02318901 | - | - | Terminated(PI no longer at sig... more >>ht. Results not collected) Collapse << | - | - |
| NCT03429101 | Breast Cancer | Phase 1 | Recruiting | February 2021 | United States, California ... more >> Pacific Cancer Medical Center, Inc. Recruiting Anaheim, California, United States, 92801 Contact: Elizabeth Brown 714-999-1465 Elizabethg@pacificcancer.com Collapse << |
| NCT00934856 | Breast Cancer | Phase 1 Phase 2 | Completed | - | United States, North Carolina ... more >> Charlotte, North Carolina, United States, 28203 United States, Texas Houston, Texas, United States, 77005 France Dijon, France, 21079 Saint Herblain, France, 44805 Spain Barcelona, Spain, 08003 Madrid, Spain, 28007 Madrid, Spain, 28040 United Kingdom Dundee, United Kingdom, DD1 9SY Collapse << |
| NCT01494662 | Breast Cancer | Phase 2 | Recruiting | December 2023 | United States, California ... more >> University of California, San Francisco Medical Center Active, not recruiting San Francisco, California, United States, 94115 United States, District of Columbia MedStar Georgetown Univeristy Hospital Active, not recruiting Washington, District of Columbia, United States, 20007 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Active, not recruiting Baltimore, Maryland, United States, 21231 United States, Massachusetts Beth Israel Deaconess Medical Center Active, not recruiting Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Rachel Freedman, MD Principal Investigator: Rachel Freedman, MD, MPH Massachusetts General Hosptial Recruiting Boston, Massachusetts, United States, 02215 Contact: Beverly Moy, MD Principal Investigator: Beverly Moy, MD United States, Michigan University of Michigan Comprehensive Cancer Center Active, not recruiting Ann Arbor, Michigan, United States, 48109 United States, North Carolina University of North Carolina at Chapel Hill - Lineberger Comprehensive Cancer Center Active, not recruiting Chapel Hill, North Carolina, United States, 27599 Duke University Medical Center Active, not recruiting Durham, North Carolina, United States, 27710 United States, Pennsylvania UPMC Cancer Centers - Magee-Womens Hospital of UPMC Active, not recruiting Pittsburgh, Pennsylvania, United States, 15213 United States, Texas Baylor College of Medicine Lester and Sue Smith Breast Center Active, not recruiting Houston, Texas, United States, 77030 MD Anderson Cancer Center Active, not recruiting Houston, Texas, United States, 77030 Collapse << |
| NCT01904903 | HER2 Positive Breast Cancer ... more >> Left Ventricular Function Systolic Dysfunction Collapse << | Phase 2 | Unknown | August 2018 | United States, District of Col... more >>umbia Washington Cancer Institute at MedStar Washington Hospital Center Recruiting Washington, District of Columbia, United States, 20010 Contact: Ronla Prince, MPA Contact: Filipa Lynce, MD Principal Investigator: Sandra M Swain, MD, FACP Sub-Investigator: Ana Barac, MD, PhD Sub-Investigator: Filipa Lynce, MD MedStar Georgetown University Hospital Recruiting Washington, District of Columbia, United States, 20057 Contact: Julie Castle 202-687-2209 bickmorj@georgetown.edu Contact: Antonella Novielli 2024443923 noviella@georgetown.edu Principal Investigator: Filipa Lynce, MD Collapse << |
| NCT03032107 | Breast Cancer | Phase 1 | Recruiting | July 1, 2024 | United States, Massachusetts ... more >> Beth Israel Deaconess Medical Center Recruiting Boston, Massachusetts, United States, 02215 Contact: Gerburg Wulf, MD PhD 617-667-1910 Principal Investigator: Gerburg Wulf, MD PhD Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Sara Tolaney, MD MPH 617-632-3779 stolaney@partners.org Principal Investigator: Sara Tolaney, MD MPH Collapse << |
| NCT02135159 | HER2-positive Breast Cancer | Phase 1 | Completed | - | France ... more >> Institut regional du Cancer - Val d Aurelle Montpellier, France, 34298 Collapse << |
| NCT00934856 | - | - | Completed | - | - |
| NCT03529110 | Breast Cancer | Phase 3 | Recruiting | February 2022 | United States, California ... more >> Cancer Research Collaboration Recruiting Santa Ana, California, United States, 92705 Contact: Principal Investigator 562-981-6101 WadeSmith@veritymed.org United States, District of Columbia Washington Cancer Institute Recruiting Washington, District of Columbia, United States, 20010 Contact: Site Coordinator 202-877-9386 mhri.oncology@medstar.net United States, New York North Shore Hematology Oncology Associates, PC Recruiting East Setauket, New York, United States, 11733 Contact: Site Coordinator 631-675-5143 dmarx@nycancer.com United States, Tennessee Tennessee Oncology- St Thomas Location Recruiting Nashville, Tennessee, United States, 37205 Contact: Site Coordinator 615-524-4016 cann.studyactivation@sarahcannon.com United States, Washington MultiCare Health System Institute for Research and Innovation Recruiting Auburn, Washington, United States, 98001 Contact: Site Coordinator 253-209-8972 srebar@multicare.org Japan Hiroshima City Hiroshima Citizens Hospital Recruiting Hiroshima, Hiroshima-Ken, Japan, 730-8518 Contact: See Central Contact Showa University Hospital Recruiting Shinagawa-Ku, Tokyo-To, Japan, 142-8666 Contact: See Central Contact Aichi Cancer Center Hospital Recruiting Aichi, Japan, 464-8681 Contact: See Central Contact NHO Hokkaido Cancer Center Recruiting Hokkaido, Japan, 003-0804 Contact: See Central Contact Kanagawa Cancer Center Recruiting Kanagawa, Japan, 241-8515 Contact: See Central Contact Niigata Cancer Center Recruiting Niigata, Japan, 951-8566 Contact: See Central Contact NHO Osaka National Hospital Recruiting Osaka, Japan, 540-0006 Contact: See Central Contact Osaka International Cancer Institute Recruiting Osaka, Japan, 541-8567 Contact: See Central Contact Satiama Cancer Center Recruiting Saitama, Japan, 362-0806 Contact: See Central Contact The Cancer Institute Hospital of JFCR Recruiting Tokyo, Japan, 135-8550 Contact: See Central Contact Collapse << |
| NCT02605915 | HER2-Positive Metastatic Breas... more >>t Cancer HER2-Negative Metastatic Breast Cancer Locally Advanced or Early Breast Cancer Collapse << | Phase 1 | Active, not recruiting | October 31, 2019 | United States, Alabama ... more >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35294-3300 United States, Arkansas University of Arkansas for Medical Sciences; Winthrop Rockefeller Cancer Institute Little Rock, Arkansas, United States, 72205 United States, Illinois Joliet oncology hematology associates Joliet, Illinois, United States, 60435 United States, Indiana Horizon Oncology Research, Inc. Lafayette, Indiana, United States, 47905 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21287 United States, Michigan Karmanos Cancer Center; Department of Oncology Detroit, Michigan, United States, 48201 United States, Missouri HCA Midwest Division Kansas City, Missouri, United States, 64132 United States, New York Montefiore Medical Center, Advanced Women's Health Center, Clinical Trials and Research Unit; Depart Bronx, New York, United States, 10461 United States, North Carolina Levine Cancer Institute Charlotte, North Carolina, United States, 28204 Duke Cancer Center Durham, North Carolina, United States, 27710 United States, Ohio Oncology Hematology Care Inc Cincinnati, Ohio, United States, 45242 United States, Pennsylvania St. Luke's University Health Network Bethlehem, Pennsylvania, United States, 18015 Kimmel Cancer Center Thomas Jefferson University Philadelphia, Pennsylvania, United States, 19107 Magee Womens Hospital Pittsburgh, Pennsylvania, United States, 15213 United States, Tennessee Tennessee Oncology - Chattanooga; Tennessee Oncology - East Third Street Chattanooga, Tennessee, United States, 37404 West Clinic Germantown, Tennessee, United States, 38138 Tennessee Oncology Nashville, Tennessee, United States, 37203 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Cancer Therapy and Research Center CTRC at UTHSCSA San Antonio, Texas, United States, 78229 United States, Wisconsin Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 Collapse << |
| NCT03203616 | Metastatic HER2-positive Breas... more >>t Cancer With Brain Metastasis Collapse << | Phase 2 | Withdrawn(As most HER2+ patien... more >>t develop brain mets while on/after having received TDM1, it has proven to be an insurmountable challenge to recruit patients) Collapse << | - | - |
| NCT01237678 | Small Cell Lung Cancer | Phase 1 Phase 2 | Terminated(Study was stopped e... more >>arly due to lack of efficacy signal and safety concerns) Collapse << | - | - |
| NCT01120184 | - | - | Completed | - | - |
| NCT01120184 | Breast Cancer | Phase 3 | Completed | - | - |
| NCT02073487 | Breast Cancer | Phase 2 | Active, not recruiting | June 2019 | United States, Texas ... more >> Houston Methodist Hospital Houston, Texas, United States, 77030 Houston Methodist Hospital Willowbrook Houston, Texas, United States, 77070 Houston Methodist Hospital Sugar Land Sugar Land, Texas, United States, 77479 Collapse << |
| NCT01853748 | Breast Cancer | Phase 2 | Active, not recruiting | December 2021 | - |
| NCT00943670 | Metastatic Breast Cancer | Phase 2 | Completed | - | - |
| NCT01237678 | - | - | Terminated(Study was stopped e... more >>arly due to lack of efficacy signal and safety concerns) Collapse << | - | - |
| NCT01983501 | HER2 Positive Breast Cancers | Phase 1 | Active, not recruiting | July 2019 | United States, Alabama ... more >> University of Alabama Birmingham, Alabama, United States, 35294 United States, Colorado University of Colorado Cancer Center Aurora, Colorado, United States, 80045 United States, Kansas University of Kansas Kansas City, Kansas, United States, 66160 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Oregon Providence Cancer Center Portland, Oregon, United States, 97213 United States, Tennessee Sarah Cannon Research Institute Nashville, Tennessee, United States, 37203 United States, Washington Northwest Medical Specialties Tacoma, Washington, United States, 98045 Canada, Ontario London Health Sciences Centre London, Ontario, Canada, N6A 5W9 Princess Margaret Cancer Centre Toronto, Ontario, Canada, M5T 2M9 Canada, Quebec Hospital de la Cite-de-la-Sante Laval, Quebec, Canada, H7M 3L9 Jewish General Hospital Montreal, Quebec, Canada, H3T 1E2 Collapse << |
| NCT02236000 | Breast Cancer | Phase 1 Phase 2 | Recruiting | July 2019 | United States, Florida ... more >> Cleveland Clinic Weston Recruiting Weston, Florida, United States, 33331 United States, Illinois Cancer Care Specialists of Central Illinois Recruiting Decatur, Illinois, United States, 62526 Crossroads Cancer Center Recruiting Effingham, Illinois, United States, 62401 Cancer Care Specialists of Central Illinois-Swansea Recruiting Swansea, Illinois, United States, 62226 United States, Ohio Cleveland Clinic Recruiting Cleveland, Ohio, United States, 44195 Contact: Diana Gosik, RN, BS 800-270-3165 United States, Oklahoma Stephenson Cancer Center at the University of Oklahoma Health Services Center Recruiting Oklahoma City, Oklahoma, United States, 73104 United States, Pennsylvania UPMC- Hillman Cancer Center-Monroeville Recruiting Monroeville, Pennsylvania, United States, 15146 Alleheny General Hospital Recruiting Pittsburgh, Pennsylvania, United States, 15212 Hillman Cancer Center Recruiting Pittsburgh, Pennsylvania, United States, 15213 Magee Womens Hospital of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Diana Gosik, RN, BS 800-270-3165 University of Pittsburgh Recruiting Pittsburgh, Pennsylvania, United States, 15213 UPMC- St. Margaret Recruiting Pittsburgh, Pennsylvania, United States, 15215 United States, Rhode Island Women & Infants Hospital of Rhode Island Recruiting Providence, Rhode Island, United States, 02905 Contact: Diana Gosik, RN, BS 800-270-3165 United States, West Virginia West Virginia University Recruiting Morgantown, West Virginia, United States, 26501 Contact: Diana Gosik, RN, BS 800-270-3165 Collapse << |
| NCT01745965 | Breast Cancer | Phase 2 | Active, not recruiting | October 2020 | Germany ... more >> Breast Center of the University of Munich (LMU) Munich, Germany Ev. Krankenhaus Bethesda Brustzentrum Niederrhien Mönchengladbach, Germany Collapse << |
| NCT00943670 | - | - | Completed | - | - |
| NCT00679211 | Metastatic Breast Cancer | Phase 2 | Completed | - | - |
| NCT02073916 | Metastatic Breast Cancer | Phase 1 | Active, not recruiting | December 2018 | United States, Texas ... more >> Houston Methodist Hospital Houston, Texas, United States, 77030 Collapse << |
| NCT00679211 | - | - | Completed | - | - |
| NCT00951665 | Metastatic Breast Cancer | Phase 1 Phase 2 | Completed | - | United States, California ... more >> Stanford, California, United States, 94305-5456 United States, Colorado Aurora, Colorado, United States, 80045 United States, Massachusetts Boston, Massachusetts, United States, 02115 United States, Michigan Detroit, Michigan, United States, 48201 United States, New York New York, New York, United States, 10065 Collapse << |
| NCT00833963 | - | - | Recruiting | January 31, 2025 | United States, North Carolina ... more >> Kendle International, Inc Recruiting Wilmington, North Carolina, United States, 28405 Collapse << |
| NCT01966471 | Breast Cancer | Phase 3 | Active, not recruiting | January 31, 2024 | - |
| NCT00951665 | - | - | Completed | - | - |
| NCT00829166 | Breast Cancer | Phase 3 | Completed | - | - |
| NCT00679341 | - | - | Completed | - | - |
| NCT01975142 | Metastatic Breast Cancer Consi... more >>dered HER2 Negative on Primary Tumor Collapse << | Phase 2 | Unknown | November 2017 | France ... more >> Clinique Victor Hugo Le Mans, France, 72000 Institut de Cancérologie HARTMANN Levallois-perret, France, 92309 Centre Oscar Lambret Lille, France, 59020 Chu de Limoges Limoges, France, 87042 Centre Val d'Aurelle - P. Lamarque Montpellier, France, 34298 Institut Curie Paris, France, 75005 Chu Saint-Louis Paris, France, 75475 Institut Curie - Hôpital René HUGENIN Saint-cloud, France, SAINT-CLOUD Centre Catherine de Sienne Vandoeuvre Les Nancy, France, 54519 Institut de Cancérologie de Lorraine Vandoeuvre Les Nancy, France, 54519 Collapse << |
| NCT00781612 | Neoplasm Metastasis | Phase 2 | Recruiting | September 21, 2022 | - |
| NCT02226276 | Bone Metastases ... more >> HER2-positive Breast Cancer Liver Metastases Lung Metastases Recurrent Breast Cancer Soft Tissue Metastases Stage IV Breast Cancer Collapse << | Not Applicable | Active, not recruiting | February 2019 | United States, California ... more >> City of Hope Medical Center Duarte, California, United States, 91010 Collapse << |
| NCT00679341 | Breast Cancer | Phase 2 | Completed | - | - |
| NCT01513083 | Breast Cancer | Phase 1 | Completed | - | United States, Florida ... more >> Fort Myers, Florida, United States, 33905 United States, Michigan Detroit, Michigan, United States, 48201 United States, Oregon Portland, Oregon, United States, 97239 United States, Tennessee Nashville, Tennessee, United States, 37203 Canada, Ontario Ottawa, Ontario, Canada, K1H8L6 Toronto, Ontario, Canada, M5G 2M9 France Marseille, France, 13273 Paris, France, 75231 Toulouse, France, 31059 Italy Catanzaro, Calabria, Italy, 88100 Udine, Friuli-Venezia Giulia, Italy, 33100 Spain Barcelona, Spain, 08003 Madrid, Spain, 28007 Collapse << |
| NCT00829166 | - | - | Completed | - | - |
| NCT03025711 | - | - | Recruiting | December 31, 2018 | Spain ... more >> Puerta de Hierro University Hospital Recruiting Madrid, Spain, 28222 Contact: Belen Ruiz-Antoran 34911917479 mariabelen.ruiz@salud.madrid.org Principal Investigator: Belen Ruiz-Antorán Collapse << |
| NCT01702558 | Solid Tumors | Phase 2 | Completed | - | - |
| NCT01772472 | Breast Cancer | Phase 3 | Active, not recruiting | April 4, 2023 | - |
| NCT02131064 | Breast Neoplasms | Phase 3 | Completed | - | - |
| NCT00509769 | - | - | Completed | - | - |
| NCT00509769 | Metastatic Breast Cancer | Phase 2 | Completed | - | - |
| NCT02131064 | - | - | Completed | - | - |
| NCT02144012 | - | - | Terminated | - | - |
| NCT02144012 | Metastatic Breast Cancer | Phase 3 | Terminated | - | Korea, Republic of ... more >> Daegu, Korea, Republic of, 702-210 Gyeonggi-do, Korea, Republic of, 410-769 Seoul, Korea, Republic of, 05505 Malaysia Sabah, Malaysia, 88996 Taiwan Taipei, Taiwan, 00112 Taipei, Taiwan, 100 Taoyuan, Taiwan, 333 Thailand Bangkok, Thailand, 10330 Collapse << |
| NCT02658734 | HER2 Positive Breast Cancer, M... more >>etastatic Breast Cancer, Locally Advanced Breast Cancer Collapse << | Phase 4 | Recruiting | December 2, 2020 | India ... more >> Indraprastha Apollo Hospitals Recruiting New Delhi, Delhi, India, 110076 Rajiv Gandhi Cancer Inst.&Research Center; Medical Oncology Recruiting New Delhi, Delhi, India, 110085 Max Super Speciality Hospital; Medical Oncology Active, not recruiting North WEST Delhi, Delhi, India, 110088 Apollo Hospitals International Limited Recruiting Gandhinagar, Gujarat, India, 382428 Manipal Hospital; Department of Oncology Recruiting Bangalore, Karnataka, India, 560017 Tata Memorial Hospital; Dept of Medical Oncology Active, not recruiting Mumbai, Maharashtra, India, 400012 Jehangir Hospital Active, not recruiting Pune, Maharashtra, India, 411001 Christian Medical College & Hospital; Medicine Recruiting Vellore, Tamil NADU, India, 632004 Healthcare Global Enterprises Limited Recruiting Bangalore, India, 560027 Vikram Hospital Bengaluru Private Limited Withdrawn Bengaluru, India, 560 052 Artemis Health Institute Active, not recruiting Gurgaon, India, 122001 Fortis Memorial Research Institute; Department of Medical Oncology & Haematology Recruiting Gurgaon, India, 122002 Sir Gangaram Hospital; Medical Oncology Completed New Delhi, India, 110 060 Dr. B L Kapur Memorial Hospital; BLK Cancer Centre Withdrawn New Delhi, India, 110005 Max Super Speciality Hospital Recruiting New Delhi, India, 110017 Collapse << |
| NCT02414646 | Estrogen Receptor Status ... more >> HER2 Positive Breast Carcinoma Progesterone Receptor Status Stage I Breast Cancer AJCC v7 Stage IA Breast Cancer AJCC v7 Stage IB Breast Cancer AJCC v7 Stage II Breast Cancer AJCC v6 and v7 Stage IIA Breast Cancer AJCC v6 and v7 Stage IIB Breast Cancer AJCC v6 and v7 Stage III Breast Cancer AJCC v7 Stage IIIA Breast Cancer AJCC v7 Stage IIIB Breast Cancer AJCC v7 Stage IIIC Breast Cancer AJCC v7 Collapse << | Phase 2 | Active, not recruiting | January 31, 2022 | United States, California ... more >> City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 United States, Illinois Illinois CancerCare-Peoria Peoria, Illinois, United States, 61615 United States, Kansas Cancer Center of Kansas - Wichita Wichita, Kansas, United States, 67214 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Michigan Michigan Cancer Research Consortium NCORP Ann Arbor, Michigan, United States, 48106 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, New York State University of New York Upstate Medical University Syracuse, New York, United States, 13210 United States, North Carolina UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina, United States, 27599 High Point Regional Hospital High Point, North Carolina, United States, 27262 FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst, North Carolina, United States, 28374 United States, Ohio Columbus NCI Community Oncology Research Program Columbus, Ohio, United States, 43215 Toledo Clinic Cancer Centers-Toledo Toledo, Ohio, United States, 43623 United States, Virginia Inova Fairfax Hospital Falls Church, Virginia, United States, 22042 Collapse << |
| NCT03225937 | Metastatic Colorectal Cancer | Phase 2 | Active, not recruiting | June 2019 | Italy ... more >> Fondazione del Piemonte per l'Oncologia - IRCCS Candiolo, Please Select, Italy, 10060 AOU Policlinico S. Orsola Malpighi Bologna, Italy Grande Ospedale Metropolitano Niguarda Milano, Italy, 20162 Seconda Università di Napoli Napoli, Italy Istituto Oncologico Veneto - IRCCS Padova, Italy Campus Biomedico Roma, Italy AOU Città della Salute e della Scienza di Torino Torino, Italy Collapse << |
| NCT03418558 | Metastatic Colorectal Cancer | Phase 2 | Recruiting | June 2019 | Italy ... more >> Fondazione del Piemonte per l'Oncologia Completed Candiolo, Italy, 10060 Grande Ospedale Metropolitano Niguarda Recruiting Milano, Italy Contact: Salvatore Siena, MD salvatore.siena@ospedaleniguarda.it IOV - Istituto Oncologico Veneto Completed Padova, Italy Collapse << |
| NCT00875979 | - | - | Completed | - | - |
| NCT03364348 | HER2 Positive Breast Carcinoma... more >> Recurrent Breast Carcinoma Stage III Breast Cancer Stage IIIA Breast Cancer Stage IIIB Breast Cancer Stage IIIC Breast Cancer Stage IV Breast Cancer Collapse << | Phase 1 | Recruiting | October 2021 | United States, California ... more >> Stanford University, School of Medicine Recruiting Palo Alto, California, United States, 94304 Contact: Oshra Sedan 650-723-0628 osedan@stanford.edu Principal Investigator: George W. Sledge, MD Collapse << |
| NCT02924883 | Metastatic Breast Cancer | Phase 2 | Active, not recruiting | November 24, 2020 | - |
| NCT00875979 | Metastatic Breast Cancer | Phase 1 Phase 2 | Completed | - | United States, Florida ... more >> Boca Raton, Florida, United States, 33428 Deerfield Beach, Florida, United States, 33442 United States, Illinois Maywood, Illinois, United States, 60153 United States, Indiana Indianapolis, Indiana, United States, 46202 United States, Kansas Wichita, Kansas, United States, 67214 United States, Maryland Rockville, Maryland, United States, 20850-3348 United States, North Carolina Chapel Hill, North Carolina, United States, 27514 United States, Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Philadelphia, Pennsylvania, United States, 19111 United States, Tennessee Nashville, Tennessee, United States, 37203 Belgium Bruxelles, Belgium, 1000 Canada, British Columbia Vancouver, British Columbia, Canada, V5Z 1H5 Canada, Quebec Montreal, Quebec, Canada, H3A 1A1 France Paris, France, 75248 Villejuif, France, 94805 Germany Köln, Germany, 50924 Italy Aviano, Italy, 33081 Milano, Italy, 20133 Spain Barcelona, Spain, 08035 Valencia, Spain, 46010 Collapse << |
| NCT02675829 | Solid Tumor Cancers ... more >> Lung Cancer Bladder Cancer Urinary Tract Cancers Collapse << | Phase 2 | Recruiting | February 2019 | United States, New York ... more >> Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Bob Li, MD 646-888-4201 Contact: Gopakumar Iyer, MD 646-422-4362 Principal Investigator: Bob Li, MD Collapse << |
| NCT02658084 | Breast Cancer ... more >> Metastatic Breast Cancer Collapse << | Phase 1 Phase 2 | Terminated(Terminated due to l... more >>ow accrual and toxicity concerns.) Collapse << | - | United States, Florida ... more >> University of Miami Miami, Florida, United States, 33136 Collapse << |
| NCT01419197 | Breast Cancer | Phase 3 | Completed | - | - |
| NCT03084939 | Breast Cancer | Phase 3 | Active, not recruiting | October 5, 2019 | China ... more >> Beijing Hospital Beijing City, China, 100006 The Affiliated Hospital of Military Medical Sciences(The 307th Hospital of Chinese PLA) Beijing, China, 100071 Beijing Cancer Hospital Beijing, China, 100142 Jilin Cancer Hospital Changchun, China, 130012 the First Hospital of Jilin University Changchun, China, 130021 Changzhou First People's Hospital Changzhou, China, 213003 West China Hospital, Sichuan University Chengdu, China, 610041 Fujian Medical University Union Hospital Fujian, China, 350001 Zhejiang Cancer Hospital; Zhejiang Cancer Hospital cancer department Hangzhou City, China, 310022 The Second Affiliated Hospital of Zhejiang University College Hangzhou, China, 310009 Harbin Medical University Cancer Hospital Harbin, China, 150081 Jiangsu Cancer Hospital Nanjing, China, 210009 Jiangsu Province Hospital Nanjing, China, 210036 Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China, 200025 Fudan University Shanghai Cancer Center Shanghai, China, 200032 Liaoning cancer Hospital & Institute Shenyang, China, 110042 Tianjin Cancer Hospital Tianjin, China, 300060 First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an, China, 710061 Collapse << |
| NCT02289833 | Non-Small Cell Lung Cancer | Phase 2 | Completed | - | United States, Florida ... more >> Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy) Jacksonville, Florida, United States, 32256 United States, Illinois Rush University Medical Center Chicago, Illinois, United States, 60612 United States, Michigan Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, North Carolina University of North Carolina at Chapel Hill Chapel Hill, North Carolina, United States, 27514 United States, Washington Seattle Cancer Care Alliance Seattle, Washington, United States, 98109 Germany HELIOS Klinikum Emil von Behring Klinik f.Pneumologie Onkologie u.Infektiologie Berlin, Germany, 14165 Kaiserswerther Diakonie Florence Nightingale-Krankenh. Tagesklinik f.Onkologie Düsseldorf, Germany, 40489 Asklepios-Fachkliniken Muenchen-Gauting; Onkologie Gauting, Germany, 82131 Krankenhaus Martha-Maria Halle-Doelau gGmbH; Klinik fuer Innere Medizin II Halle, Germany, 06120 Fachklinik für Lungenerkrankungen Immenhausen, Germany, 34376 Italy Azienda Ospedaliera Univ Parma; Dept Oncologia Medica Parma, Emilia-Romagna, Italy, 43100 Istituto Europeo Di Oncologia Milano, Lombardia, Italy, 20141 Korea, Republic of Seoul National University Hospital Seoul, Korea, Republic of, 03080 Asan Medical Center Seoul, Korea, Republic of, 05505 Poland Medical University of Gdansk Gdansk, Poland, 80-211 Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy; Oddzial Iii Otwock, Poland, 05-400 Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie Klinika Nowotworów Piersi i Chirurgii Warszawa, Poland, 02-781 Spain Hospital Univ Vall d'Hebron; Servicio de Oncologia Barcelona, Spain, 08035 Hospital Ramon y Cajal; Servicio de Oncologia Madrid, Spain, 28034 Hospital Universitario La Paz; Servicio de Oncologia Madrid, Spain, 28046 Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia Zaragoza, Spain, 50009 Switzerland CHUV; Departement d'Oncologie Lausanne, Switzerland, 1011 UniversitätsSpital Zürich; Zentrum für Hämatologie und Onkologie, Klinik für Onkologie Zürich, Switzerland, 8091 Collapse << |
| NCT01419197 | - | - | Completed | - | - |
| NCT02289833 | - | - | Completed | - | - |
| NCT01702571 | Breast Cancer | Phase 3 | Active, not recruiting | September 30, 2019 | - |
| NCT01816035 | HER2/Neu Positive ... more >> Recurrent Breast Carcinoma Stage IIIB Breast Cancer Stage IIIC Breast Cancer Stage IV Breast Cancer Collapse << | Phase 1 | Completed | - | United States, Washington ... more >> Fred Hutch/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 Collapse << |
| NCT01641939 | - | - | Terminated | - | - |
| NCT02254044 | Carcinoma, Squamous Cell | Phase 1 | Terminated | - | - |
| NCT02999672 | Bladder Cancer ... more >> Pancreas Cancer Cholangiocellular Carcinoma Collapse << | Phase 2 | Completed | - | Italy ... more >> IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica Meldola, Emilia-Romagna, Italy, 47014 Irccs Ospedale San Raffaele;Oncologia Medica Milano, Lombardia, Italy, 20132 Irccs Istituto Europeo Di Oncologia (IEO); Cure Mediche Milano, Lombardia, Italy, 20141 IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Prima Padova, Veneto, Italy, 35128 A.O.U.I. VERONA-OSPEDALE POLICLINICO G.B. ROSSI BORGO ROMA;ONCOLOGIA MEDICA-d.U. Verona, Veneto, Italy, 37134 Netherlands Antoni van Leeuwenhoek Ziekenhuis Amsterdam, Netherlands, 1066 CX VU Medisch Centrum Amsterdam, Netherlands, 1081 HV UMCG NL -groningen, Netherlands, 9700 RB Erasmus MC - Centrum NL -rotterdam, Netherlands, 3000 CA Slovakia Narodny onkologicky ustav Bratislava, Slovakia, 833 10 Spain Complejo Hospitalario de Navarra Pamplona, Navarra, Spain, 31008 Hospital Univ Vall d'Hebron; Servicio de Oncologia Barcelona, Spain, 08035 Hospital Duran i Reynals; Oncologia Barcelona, Spain, 08907 Hospital Ramon y Cajal; Servicio de Oncologia Madrid, Spain, 28034 Hospital Universitario 12 de Octubre; Servicio de Oncologia Madrid, Spain, 28041 Hospital Regional Universitario Carlos Haya; Servicio de Oncologia Malaga, Spain, 29010 Collapse << |
| NCT02420873 | Leukemia | Phase 2 | Completed | - | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01641939 | Gastric Cancer | Phase 2 Phase 3 | Terminated | - | - |
| NCT02254031 | Breast Neoplasms | Phase 1 | Terminated | - | - |
| NCT02420873 | - | - | Completed | - | - |
| NCT01196052 | - | - | Completed | - | - |
| NCT02254005 | Breast Neoplasms | Phase 1 | Completed | - | - |
| NCT03153163 | Breast Neoplasms | Phase 1 | Completed | - | China ... more >> Fudan University Shanghai Cancer Center; Medical Oncology Shanghai, China, 200032 Collapse << |
| NCT02254018 | Head and Neck Neoplasms | Phase 1 | Completed | - | - |
| NCT02452554 | Pleuropulmonary Blastoma ... more >> Recurrent Malignant Peripheral Nerve Sheath Tumor Recurrent Neuroblastoma Recurrent Rhabdomyosarcoma Recurrent Synovial Sarcoma Wilms Tumor Collapse << | Phase 2 | Active, not recruiting | - | - |
| NCT01196052 | Breast Cancer | Phase 2 | Completed | - | - |
| NCT02725541 | Breast Cancer | Phase 2 | Withdrawn(loss of funding supp... more >>ort) Collapse << | May 2019 | United States, Texas ... more >> Houston Methodist Hospital Houston, Texas, United States, 77030 Collapse << |
| 靶点 | Description | IC50 |
|---|
