|1,4-二氢-6,7-二硝基-2,3-喹喔啉二酮|CsnPharm

CAS No.: 2379-57-9

DNQX/二硝基喹酮 Catalog No. CSN10853

Synonyms: FG 9041;6,7-Dinitroquinoxaline-2,3-dione;二硝基喹酮

DNQX is a selective non-NMDA iGluR antagonist.

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技术信息

生物活性

描述DNQX, a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 microliters of 0.5 mg/ml) significantly diminished PCP (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex. The most dramatic decrease of hsp70 induction was seen with the intraventricular dose of DNQX^[3]. Bilateral injection of DNQX (1 microgram/0.5 microliters/side) inhibited acquisition of place preference to amphetamine (1 mg/kg) but not morphine (10 mg/kg). During acquisition, DNQX marginally attenuated the locomotor stimulation elicited by amphetamine during the first but not subsequent training sessions, while the combination of morphine plus DNQX produced marked akinesia during each training session^[4]. DNQX (6,7-dinitroquinoxaline-2,3-dione), as a quinoxaline derivatives, is a non-NMDA (N-methyl-D-aspartate) receptor antagonist. DNQX and CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) produced a consistent depolarization in all TRN (thalamic reticular nucleus) neurons tested. The DNQX- and CNQX-mediated depolarizations are mediated by AMPAR (transmembrane AMPA receptor) but not kainate receptors in TRN neurons. Quinoxaline derivatives could modulate synaptic transmission and alter neuronal excitability^[5]. DNQX toxic effect is neuron-specific since cultured hippocampal glial cells are unaffected. DNQX toxicity in cultured hippocampal neurons is apparently mediated through an ionotropic glutamate receptor-independent way^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.9660 mL
- 19.8302 mL
- 39.6604 mL
- 5 mM
- 0.7932 mL
- 3.9660 mL
- 7.9321 mL
- 10 mM
- 0.3966 mL
- 1.9830 mL
- 3.9660 mL

技术信息

CAS号

2379-57-9

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C8H4N4O6

运输

蓝冰

分子量

252.14

别名

FG 9041;6,7-Dinitroquinoxaline-2,3-dione;二硝基喹酮

溶解度

DMSO	54.0 mg/mL (214.2 mM)
Water	insoluble

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