|(S)-2-((S)-2-(二甲基氨基)-3-甲基丁酰胺基)-N-((3R,4S,5S)-3-甲氧基-1-((S)-2-((1R,2R)-1-甲氧基-2-甲基-3-氧代-3-(((S)-2-苯基-1-(噻唑-2-基)乙基)氨基)丙基)吡咯烷-1-基)-5-甲基-1-氧代庚烷-4-基)-N,3-二甲基丁酰胺|CsnPharm

CAS No.: 110417-88-4

Dolastatin 10/多拉司他丁 10 Catalog No. CSN17468

Synonyms: DLS 10;NSC 376128;多拉司他丁 10

Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly. Dolastatin and Dolastatin's analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE)

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描述Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly. Dolastatin and Dolastatin's analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE)
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00005579	Leukemia Lymp... more >>homa Collapse <<	Phase 2	Completed	-	United States, Maryland ... more >> Marlene and Stewart Greenebaum Cancer Center, University of Maryland Baltimore, Maryland, United States, 21201 United States, Michigan Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201-1379 United States, Ohio Arthur G. James Cancer Hospital - Ohio State University Columbus, Ohio, United States, 43210-1240 United States, Vermont Vermont Cancer Center Burlington, Vermont, United States, 05401-3498 Collapse <<
NCT00003693	Leukemia Myel... more >>odysplastic Syndromes Collapse <<	Phase 1	Completed	-	United States, Texas ... more >> University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030-4009 Collapse <<
NCT00003914	Kidney Cancer	Phase 2	Completed	-	United States, Arizona ... more >> Mayo Clinic Scottsdale Scottsdale, Arizona, United States, 85259 United States, Florida Mayo Clinic Jacksonville Jacksonville, Florida, United States, 32224 United States, Minnesota Mayo Clinic Cancer Center Rochester, Minnesota, United States, 55905 Collapse <<

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参考文献

[1] Pettit GR, Hogan F, Toms S. Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications of dolastatin 10. J Nat Prod. 2011 May 27;74(5):962-8.
[2] Pitot HC, McElroy EA Jr, et al. Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors. Clin Cancer Res. 1999 Mar;5(3):525-31.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2737 mL
- 6.3687 mL
- 12.7374 mL
- 5 mM
- 0.2547 mL
- 1.2737 mL
- 2.5475 mL
- 10 mM
- 0.1274 mL
- 0.6369 mL
- 1.2737 mL

技术信息

CAS号	110417-88-4	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C42H68N6O6S	运输	蓝冰
分子量	785.09	别名	DLS 10;NSC 376128;多拉司他丁 10

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00005579	Leukemia Lymp... more >>homa Collapse <<	Phase 2	Completed	-	United States, Maryland ... more >> Marlene and Stewart Greenebaum Cancer Center, University of Maryland Baltimore, Maryland, United States, 21201 United States, Michigan Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201-1379 United States, Ohio Arthur G. James Cancer Hospital - Ohio State University Columbus, Ohio, United States, 43210-1240 United States, Vermont Vermont Cancer Center Burlington, Vermont, United States, 05401-3498 Collapse <<
NCT00003693	Leukemia Myel... more >>odysplastic Syndromes Collapse <<	Phase 1	Completed	-	United States, Texas ... more >> University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030-4009 Collapse <<
NCT00003914	Kidney Cancer	Phase 2	Completed	-	United States, Arizona ... more >> Mayo Clinic Scottsdale Scottsdale, Arizona, United States, 85259 United States, Florida Mayo Clinic Jacksonville Jacksonville, Florida, United States, 32224 United States, Minnesota Mayo Clinic Cancer Center Rochester, Minnesota, United States, 55905 Collapse <<
NCT00003557	Extrahepatic Bile Duct Cancer ... more >> Gallbladder Cancer Liver Cancer Collapse <<	Phase 2	Completed	-	United States, Illinois ... more >> University of Illinois at Chicago Chicago, Illinois, United States, 60612 University of Chicago Cancer Research Center Chicago, Illinois, United States, 60637 Louis A. Weiss Memorial Hospital Chicago, Illinois, United States, 60640 Cancer Care Specialists of Central Illinois, S.C. Decatur, Illinois, United States, 62526 Evanston Northwestern Health Care Evanston, Illinois, United States, 60201 Lutheran General Cancer Care Center Park Ridge, Illinois, United States, 60068 Illinois Oncology Research Association Peoria, Illinois, United States, 61602 Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 62701 United States, Indiana Fort Wayne Medical Oncology and Hematology, Inc. Fort Wayne, Indiana, United States, 46885-5099 Michiana Hematology/Oncology P.C. South Bend, Indiana, United States, 46617 United States, Texas University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse <<
NCT00003626	Prostate Cancer	Phase 2	Completed	-	United States, Colorado ... more >> University of Colorado Cancer Center Denver, Colorado, United States, 80262 United States, Michigan Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Pennsylvania Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111 Collapse <<
NCT00003778	Ovarian Cancer ... more >> Sarcoma Collapse <<	Phase 2	Completed	-	United States, Colorado ... more >> University of Colorado Cancer Center Denver, Colorado, United States, 80262 United States, Minnesota Mayo Clinic Cancer Center Rochester, Minnesota, United States, 55905 United States, Ohio Arthur G. James Cancer Hospital - Ohio State University Columbus, Ohio, United States, 43210 United States, Pennsylvania Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111 Collapse <<
NCT00003677	Pancreatic Cancer	Phase 2	Completed	-	United States, Illinois ... more >> University of Chicago Cancer Research Center Chicago, Illinois, United States, 60637 United States, Texas University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse <<

Dolastatin 10/多拉司他丁 10 Catalog No. CSN17468

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