CAS No.: 1186222-89-8
Domatinostat tosylate Catalog No. CSN17531
Synonyms: 4SC-202;4SC-202 4-Methylbenzenesulfonate
4SC-202 is an orally available potent HDACi specific for class I HDAC isoenzymes (NO HDAC8) with IC50s of 1.2/1.12/0.57 μM for HDAC1/2/3, demonstrating high selectivity over ClassIIa/IIb/III HDACs.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03278665 Malignant Melanoma Phase 1 Phase 2 Recruiting December 2020 Germany ... more >> Universitätsklinikum Essen Recruiting Essen, Germany Medizinische Hochschule Hannover Recruiting Hannover, Germany Universitätsklinikum Heidelberg Recruiting Heidelberg, Germany Klinikum der Universität München Recruiting München, Germany Universitätsklinikum Tübingen Recruiting Tübingen, Germany Universitätsklinikum Würzburg Recruiting Würzburg, Germany Collapse << NCT01344707 Advanced Hematologic Malignanc... more >>ies Collapse << Phase 1 Completed - Germany ... more >> Universiätsklinikum Köln Köln, Germany Robert-Bosch-Krankenhaus Stuttgart, Germany Universitätsklinikum Würzburg Würzburg, Germany Collapse << - 参考文献
- [1] Pinkerneil M, Hoffmann MJ, et al. Evaluation of the Therapeutic Potential of the Novel Isotype Specific HDAC Inhibitor 4SC-202 in Urothelial Carcinoma Cell Lines. Target Oncol. 2016 Dec;11(6):783-798.
- [2] Zhijun H, Shusheng W, et al. Pre-clinical characterization of 4SC-202, a novel class I HDAC inhibitor, against colorectal cancer cells. Tumour Biol. 2016 Aug;37(8):10257-67.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1186222-89-8 | 储存条件 |
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| 分子式 | C30H29N5O6S2 | 运输 | 蓝冰 | |
| 分子量 | 619.71 | 别名 | 4SC-202;4SC-202 4-Methylbenzenesulfonate |
