|(2S,2a'E,2a1'S,4'E,5S,6R,6'S,7'S,8'E,11'R,15'S,17a'R,20'R,20a'R)-6-环己基-2a1',20'-二羟基-7'-(((2R,4S,5S,6S)-5-(((2S,4S,5S,6S)-5-羟基-4-甲氧基-6-甲基四氢-2H-吡喃-2-基)氧基)-4-甲氧基-6-甲基四氢-2H-吡喃-2-基)氧基)-5,6',8',19'-四甲基-2a1',5,6,6',7',10',11',14',15',17a',20',20a'-十二氢-2'H,17'H-螺[吡喃-2,13'-[11,15]甲桥[1,5]二氧杂环十八并[9,8,7-cd]苯并呋喃]-17'-酮|CsnPharm

CAS No.: 117704-25-3

Doramectin/多拉菌素 Catalog No. CSN10857

Synonyms: Cyclohexylavermectin B1;Dectomax;UK 67994

Doramectin is a mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins.

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400-920-2911

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技术信息

生物活性

描述Doramectin is an antiparasitic agent. Doramectin at 0.5 mg/kg once a day is effective in the elimination of Spirocerca lupi nodules in dogs^[3]. Moreover, oral administration of doramectin twice a week does not achieve a more rapid resolution of canine generalized demodicosis than administration by subcutaneous injection once a week. The treatment success rate was the same for both protocols^[4]. Guinea pigs naturally infested by T. caviae mites can be cured safely using two doses of doramectin once in a week (Doramectin 1 % (w/v) was administered intramuscularly at a dose rate of 400 μg/kg once weekly) ^[5]. Doramectin administration at 1 mg/kg b.wt. of fish incorporated in feed and given orally for 10 days or by a single intramuscular injection at 200 μg/kg b.wt. was found to be effective in controlling L. cyprinacea adult parasite infection in P. pulchellus^[6]. The rabbits treated subcutaneously with doramectin at a single dose of 200 μg /kg bw showed a very low effect, although there was significant improvement when the dose was doubled to 400 μg /kg bw, with the number of mites counted decreasing significantly^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1122 mL
- 5.5610 mL
- 11.1221 mL
- 5 mM
- 0.2224 mL
- 1.1122 mL
- 2.2244 mL
- 10 mM
- 0.1112 mL
- 0.5561 mL
- 1.1122 mL

技术信息

CAS号

117704-25-3

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C50H74O14

运输

蓝冰

分子量

899.11

别名

Cyclohexylavermectin B1;Dectomax;UK 67994;多拉菌素

溶解度

DMSO	49.0 mg/mL (54.5 mM)

动物实验配方

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