|1-乙基-4-(2-吗啉乙基)-3,3-二苯基吡咯烷-2-酮盐酸盐水合物|CsnPharm

CAS No.: 7081-53-0

Doxapram HCl/多沙普仑盐酸一水合物 Catalog No. CSN16013

Synonyms: Doxapram (hydrochloride hydrate);AHR 619;Doxapram HCl hydrate

Doxapram HCl, a respiratory stimulant, exhibits inhibition of TASK-1 (EC50 = 410 nM), TASK-3 (EC50 = 37 nM) and TASK-1/TASK-3 heterodimeric (EC50 = 9 nM) channel function. It is widely used in central nervous system excitability and directly stimulate the medullary respiratory or vascular movement center.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 Potassium Channel TASK3

EC50:37μM Potassium Channel TASK1

EC50:410nM Potassium Channel TASK1/TASK3

EC50:9μM
描述Doxapram Hydrochloride Monohydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively^[3]. Doxapram (15 - 150 microM) also evoked 3H overflow in a concentration dependent manner, and doxapram-evoked release was inhibited by the Ca2+ channel blocker nifedipine (5 microM)^[4]. Doxapram (1 - 100 microM) caused rapid, reversible and dose-dependent inhibitions of K+ currents recorded in type I cells (IC50 approximately 13 microM). Inhibition was voltage-dependent, in that the effects of doxapram were maximal at test potentials where a shoulder in the current-voltage relationship was maximal. Doxapram (10 microM) was without effect on L-type Ca2+ channel currents recorded under conditions where K+ channel activity was minimized and was also without significant effect on K+ currents recorded in the neuronal cell line NG-108-15, suggesting a selective effect on carotid body type I cells^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3096 mL
- 11.5479 mL
- 23.0958 mL
- 5 mM
- 0.4619 mL
- 2.3096 mL
- 4.6192 mL
- 10 mM
- 0.2310 mL
- 1.1548 mL
- 2.3096 mL

技术信息

CAS号

7081-53-0

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H33ClN2O3

运输

蓝冰

分子量

432.98

别名

Doxapram (hydrochloride hydrate);AHR 619;Doxapram HCl hydrate;Doxapram hydrochloride;多沙普仑盐酸一水合物;盐酸多沙普仑

溶解度

DMSO	87.0 mg/mL (200.9 mM)
Water	24.0 mg/mL (55.4 mM)
Ethanol	2.0 mg/mL (4.6 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

靶点	Description	IC50
Potassium Channel TASK3		EC50:37μM
Potassium Channel TASK1		EC50:410nM
Potassium Channel TASK1/TASK3		EC50:9μM

Doxapram HCl/多沙普仑盐酸一水合物 Catalog No. CSN16013

靶点选择性

请登录您的专属账户

确认信息