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CAS No.: 536-43-6

Dyclonine HCl/盐酸达克罗宁 Catalog No. CSN10881

Synonyms: Dyclocaine hydrochloride;Dyclocaine HCl;Dyclonine (hydrochloride)

Dyclonine HCl is the HCl form of dyclonine which can reversibly bind to activated sodium channels on the neuronal membrane. It is an anaesthetic found in sucrets.

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技术信息

生物活性

描述Dyclonine hydrochloride is the hydrochloride salt of Dyclonine. It reversibly binds to activated sodium channels in the neuron membrane, thereby decreasing the neuronal membrane's permeability to sodium ions. This results in a transient and reversible loss of sensation in a localized area of body. It is recently reported to act as a covalent inhibitor for aldehyde dehydrogenases (ALDHs). Dyclonine hydrochloride (50 µM; 24 h) sensitizes cancer cells to deficiency of cysteine and GSH. Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 24 days) sensitizes the involucrin+ differentiated tumor cells to sulfasalazine treatment in vivo. Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 21 days) suppress the growth of tumors formed by ALDH3A1-expressing gastric cancer stemlike cells when combines with sulfasalazine^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03352700	Bowel Preparation Scale ... more >> the Amount of Air Bubble Adenoma Detection Rate Collapse <<	Phase 4	Not yet recruiting	February 1, 2018	China ... more >> Changhai Hospital, Second Military Medical University Shanghai, China, 200433 Collapse <<
NCT03352700	Bowel Preparation Scale ... more >> the Amount of Air Bubble Adenoma Detection Rate Collapse <<	Phase 4	Not yet recruiting	February 1, 2018	China ... more >> Changhai Hospital, Second Military Medical University Shanghai, China, 200433 Collapse <<

参考文献

[1] Gargiulo AV, Burns GM, Huck CP. Dyclonine hydrochloride--a topical agent for managing pain. Ill Dent J. 1992 Jul-Aug;61(4):303-4.
[2] Florestano HJ, Bahler ME. Antimicrobial properties of dyclonine hydrochloride, a new topical anesthetic. J Am Pharm Assoc Am Pharm Assoc (Baltim), 1956. 45(5): p. 320-5.
[3] Okazaki S, Shintani S, Hirata Y, et al. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget. 2018;9(73):33832-33843.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0687 mL
- 15.3434 mL
- 30.6868 mL
- 5 mM
- 0.6137 mL
- 3.0687 mL
- 6.1374 mL
- 10 mM
- 0.3069 mL
- 1.5343 mL
- 3.0687 mL

技术信息

CAS号

536-43-6

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H28ClNO2

运输

蓝冰

分子量

325.87

别名

Dyclocaine hydrochloride;Dyclocaine HCl;Dyclonine (hydrochloride);Dyclone;Dyclothane;Tanaclone;Dyclonine Hydrochloride;Dyclonine HCL;Sucrets;Tanac;盐酸达克罗宁

溶解度

DMSO	15.0 mg/mL (46.0 mM)
Ethanol	35.0 mg/mL (107.4 mM)

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