生物活性

• 描述Elesclomol, an inhibitor of HSP90, is a potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells.
• 细胞研究
• Cell Data

  Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
  647-V cell	-	Growth inhibition assay	-	Inhibition of human 647-V cell growth in a cell viability assay, IC50=6.9 nM	SANGER
  697 cell	-	Growth inhibition assay	-	Inhibition of human 697 cell growth in a cell viability assay, IC50=6.13 nM	SANGER
  A2780 cell	-	Growth inhibition assay	-	Inhibition of human A2780 cell growth in a cell viability assay, IC50=0.594 nM	SANGER

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• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00088088	Stage IIIB Non-Small Cell Lung... more >> Cancer Stage IV Non-Small Cell Lung Cancer Collapse <<	Phase 1 Phase 2	Completed	-	United States, Arkansas ... more >> NEA Clinic Jonesboro, Arkansas, United States, 72401 United States, California Wilshire Oncology Medical Group Pamona, California, United States, 91767 St. Francis Memorial Hospital San Francisco, California, United States Cancer Institute Medical Group Santa Monica, California, United States, 90404 Kaiser Permanete Vallejo, California, United States United States, Connecticut Oncology Associates of Bridgeport Trumball, Connecticut, United States, 06611 United States, Florida ACORN Miami, Florida, United States Oncology Hematology Consultants Sarasota, Florida, United States, 34236 United States, Illinois University of Chicago Chicago, Illinois, United States, 60637 The Cancer Institute at Alexian Brothers Elk Grove Village, Illinois, United States, 60007 Ingalls Hospital Harvey, Illinois, United States, 60426 United States, Louisiana Overton Brooks, VAMC Shreveport, Louisiana, United States, 71101 LSUHSC - Shreveport Feist Weiller Cancer Center Shreveport, Louisiana, United States, 71130 United States, Maryland Maryland Hematology and Oncology Associates Baltimore, Maryland, United States, 21236 United States, Minnesota The Duluth Clinic Duluth, Minnesota, United States, 55805 United States, Tennessee The West Clinic Memphis, Tennessee, United States, 38120 The Sarah Cannon Research Center Nashville, Tennessee, United States, 37203 United States, Texas Presbyterian Hospital Dallas, Texas, United States, 75231 United States, Washington Multicare Health System Tacoma, Washington, United States, 98405 Collapse <<
  NCT00087997	Soft Tissue Sarcoma	Phase 2	Completed	-	-
  NCT00522834	Melanoma	Phase 3	Terminated	-	-

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• 参考文献

• [1] Foy JP, Bazire L, et al. A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes. BMC Med. 2017;15(1):165.

  [2] Kirshner JR, He S, et al. Elesclomol induces cancer cell apoptosis through oxidative stress. Mol Cancer Ther. 2008 Aug;7(8):2319-27.