|(2R,2'R,3S,3'S,4S,4'S,5R,5'R,6S,6'S)-6,6'-((((1R,3aR,4S,6aS)-六氢呋喃并[3,4-c]呋喃-1,4-二基)双(2,6-二甲氧基-4,1-亚苯基))双(氧基))双(2-(羟甲基)四氢-2H-吡喃-3,4,5-三醇 )|CsnPharm

CAS No.: 39432-56-9

Eleutheroside E/刺五加苷E Catalog No. CSN10900

Synonyms: Syringin E;刺五加苷E

Eleutheroside E, a principal component of Eleutherococcus enticosus, has anti-inflammatory and protective effects in ischemia heart.

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400-920-2911

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技术信息

生物活性

描述Eleutheroside E (EE), a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory and protective effects in ischemia heart. EE increased the insulin-provoked glucose uptake in C2C12 myotubes. Moreover, EE improved TNF- α -induced suppression of glucose uptake in 3T3-L1 adipocytes. EE mediates the hyperglycemic effects of ES by regulating insulin signaling and glucose utilization^[3]. The IC50 values for EB and EE were calculated to be 193.20 μM and 188.36 μM for CYP2E1, 595.66 μM and 261.82 μM for CYP2C9, respectively^[4]. EE administration attenuated the cardiomyocyte apoptosis induced by hypoxia-reoxygenation (H/R) injury. Further, pre-treatment with EE dramatically inhibited mitochondrial oxidative stress, IκBα phosphorylation and nuclear factor kappa B (NF-κB) subunit p65 translocation into nuclei. EE might suppress the MAPK signaling pathway to inhibit the H/R-induced NF-κB activation. EE may be a potential drug for myocardial I/R injury by reducing oxidative stress, NF-κB activation, and metabolic reprogramming^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.3464 mL
- 6.7320 mL
- 13.4641 mL
- 5 mM
- 0.2693 mL
- 1.3464 mL
- 2.6928 mL
- 10 mM
- 0.1346 mL
- 0.6732 mL
- 1.3464 mL

技术信息

CAS号

39432-56-9

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C34H46O18

运输

蓝冰

分子量

742.72

别名

Syringin E;刺五加苷E

溶解度

DMSO	100.0 mg/mL (134.6 mM)

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